| Autor: |
Sun YN; Pediatric Intensive Care Unit, Shunde Women's and Children's Hospital of Guangdong Medical University, Foshan, Guangdong, China (mainland)., Lin CW; Pediatric Intensive Care Unit, Shunde Women's and Children's Hospital of Guangdong Medical University, Foshan, Guangdong, China (mainland)., Tang W; Children's Intensive Care Unit, First Affiliated Hospital of Sun yat-sen University, Guangzhou, Guangdong, China (mainland)., Zhang JP; Pediatric Intensive Care Unit, Shunde Women's and Children's Hospital of Guangdong Medical University, Foshan, Guangdong, China (mainland). |
| Jazyk: |
angličtina |
| Zdroj: |
Medical science monitor : international medical journal of experimental and clinical research [Med Sci Monit] 2021 Dec 18; Vol. 27, pp. e933400. Date of Electronic Publication: 2021 Dec 18. |
| DOI: |
10.12659/MSM.933400 |
| Abstrakt: |
BACKGROUND The N-terminal fragment of proB-type natriuretic peptide (NT-proBNP) is an established predictive marker for sepsis-related mortality in adult. This retrospective study aimed to determine age-stratified cut-off values for serum levels of NT-proBNP and mortality from sepsis in children under 18 years. MATERIAL AND METHODS Patients were stratified by age as follows: <1 year, 1-3 years, 4-6 years, and 7-18 years (age groups). The control group consisted of age- and sex-matched healthy children. Serum NT-proBNP levels were detected by laboratory assays in the participants. The appropriate serum NT-proBNP cut-off values for predicting short-term mortality of the sepsis patients were calculated via receiver operating characteristic (ROC) curve analyses. RESULTS Among 327 pediatric patients with sepsis, the serum NT-proBNP cut-off concentrations for predicting sepsis-related mortality in the <1 year, 1-3 years, 4-6 years, and 7-18 years age groups were 5000 ng/L, 4500 ng/L, 4100 ng/L, and 3800 ng/L, respectively (P<0.001). The area under the ROC curve (AUC) values for these were 0.815, 0.812, 0.806 and 0.725, respectively (P<0.001). CONCLUSIONS This retrospective study provided the age range-specific serum NT-proBNP cut- off concentrations for predicting short-term mortality in children. In children <1 year, 1-3 years, 4-6 years, and 7-18 years, age-stratified cut-off values that predicted sepsis-associated mortality were 5000 ng/L, 4500 ng/L, 4100 ng/L, and 3800 ng/L, respectively. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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