Composition of fine particulate matter and risk of preterm birth: A nationwide birth cohort study in 336 Chinese cities.

Autor: He Y; National Research Institute for Health and Family Planning, Beijing, China; National Human Genetic Resources Center, Beijing, China., Jiang Y; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China., Yang Y; National Research Institute for Health and Family Planning, Beijing, China., Xu J; National Research Institute for Health and Family Planning, Beijing, China., Zhang Y; National Research Institute for Health and Family Planning, Beijing, China., Wang Q; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China., Shen H; National Research Institute for Health and Family Planning, Beijing, China., Zhang Y; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China., Yan D; Department of Maternal and Child Health, National Health Commission of the People's Republic of China, Beijing, China., Peng Z; National Research Institute for Health and Family Planning, Beijing, China., Liu C; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China., Wang W; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China., Schikowski T; Leibniz Research Institute for Environmental Medicine, Düsseldorf, Germany., Li H; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Yan B; Division of Geochemistry, Lamont-Doherty Earth Observatory of Columbia University, Palisades, New York, USA., Ji JS; Vanke School of Public Health, Tsinghua University, Beijing, China., Chen A; Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania, 423 Guardian Drive, Philadelphia, PA, USA., van Donkelaar A; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Martin R; Department of Physics and Atmospheric Science, Dalhousie University, Halifax, NS, Canada; Department of Energy, Environmental & Chemical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Chen R; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China., Kan H; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China; Children's Hospital of Fudan University, National Center for Children's Health, Shanghai 201102, China., Cai J; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Lab of Health Technology Assessment, Fudan University, Shanghai 200032, China. Electronic address: jingcai@fudan.edu.cn., Ma X; National Research Institute for Health and Family Planning, Beijing, China; National Human Genetic Resources Center, Beijing, China. Electronic address: xmgenetic@126.com.
Jazyk: angličtina
Zdroj: Journal of hazardous materials [J Hazard Mater] 2022 Mar 05; Vol. 425, pp. 127645. Date of Electronic Publication: 2021 Nov 01.
DOI: 10.1016/j.jhazmat.2021.127645
Abstrakt: Background: Potential hazards of fine particulate matter (PM 2.5 ) constituents on preterm birth (PTB) have rarely been explored in China.
Objective: To quantify the associations of PM 2.5 constituents with PTB.
Methods: This study was based on a nationwide cohort of 3,723,169 live singleton births delivered between January 2010 and December 2015 in China. We applied satellite-based estimates of 5 PM 2.5 constituents (organic carbon; black carbon; sulfate; ammonium; and nitrate). We used Cox proportional hazards regression models adjusted for individual covariates, temperature, humidity, and seasonality to evaluate the associations.
Results: During the entire pregnancy, each interquartile range (29 μg/m 3 ) increase in PM 2.5 concentrations was associated with a 7% increase in PTB risk [hazard ratio (HR): 1.07; 95% confidence interval (CI): 1.07-1.08). We observed the largest effect estimates on carbonaceous components (HR: 1.09; 95% CI: 1.08-1.10 for organic carbon and black carbon). Early pregnancy appeared to be the critical exposure window for most constituents. Women who were older, exposed to second-hand smoke, overweight or obese before pregnancy, conceived during winter, and living in northern China or rural areas were more susceptible.
Conclusions: Carbonaceous components of PM 2.5 were associated with higher PTB risk. Findings on characteristics of vulnerability underlined targeted protections on susceptible subgroups.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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