Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review.

Autor: Backes EH; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil., Harb SV; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil., Beatrice CAG; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil., Shimomura KMB; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil., Passador FR; Science and Technology Institute, Federal University of São Paulo, São Paulo, Brazil., Costa LC; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil., Pessan LA; Materials Engineering Department, Graduate Program in Materials Science and Engineering, Federal University of São Carlos, São Carlos, Brazil.
Jazyk: angličtina
Zdroj: Journal of biomedical materials research. Part B, Applied biomaterials [J Biomed Mater Res B Appl Biomater] 2022 Jun; Vol. 110 (6), pp. 1479-1503. Date of Electronic Publication: 2021 Dec 17.
DOI: 10.1002/jbm.b.34997
Abstrakt: Polycaprolactone (PCL) has been extensively applied on tissue engineering because of its low-melting temperature, good processability, biodegradability, biocompatibility, mechanical resistance, and relatively low cost. The advance of additive manufacturing (AM) technologies in the past decade have boosted the fabrication of customized PCL products, with shorter processing time and absence of material waste. In this context, this review focuses on the use of AM techniques to produce PCL scaffolds for various tissue engineering applications, including bone, muscle, cartilage, skin, and cardiovascular tissue regeneration. The search for optimized geometry, porosity, interconnectivity, controlled degradation rate, and tailored mechanical properties are explored as a tool for enhancing PCL biocompatibility and bioactivity. In addition, rheological and thermal behavior is discussed in terms of filament and scaffold production. Finally, a roadmap for future research is outlined, including the combination of PCL struts with cell-laden hydrogels and 4D printing.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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