Chemotherapeutic and Safety Profile of a Fraction from Mimosa caesalpiniifolia Stem Bark.

Autor: Pinheiro Ferreira PM; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Drumond RR; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Silva JDN; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil.; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil., Oliveira Sousa IJ; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., Oliveira Barros de Alencar MV; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetic Toxicology (Lapgenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., Oliveira Ferreira da Mata AM; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetic Toxicology (Lapgenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., Nery Monção NB; Department of Chemistry, Federal University of Piauí, Teresina, Brazil., Maria das Graças Lopes Citó A; Department of Chemistry, Federal University of Piauí, Teresina, Brazil., Urano Carvalho AF; Department of Biology, Federal University of Ceará, Fortaleza, Brazil., Farias DF; Department of Molecular Biology, Federal University of Paraíba, João Pessoa, Brazil., Marçal da Costa P; Faculty of Medicine, State University of Ceará, Fortaleza, Brazil., Viana Nunes AM; Laboratory of Experimental Cancerology (LabCancer), Department of Biophysics and Physiology, Federal University of Piauí, Teresina, Brazil., Marcelo de Castro E Sousa J; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetic Toxicology (Lapgenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil., Amélia de Carvalho Melo-Cavalcante A; Postgraduate Program in Pharmaceutical Sciences, Federal University of Piauí, Teresina, Brazil.; Laboratory of Genetic Toxicology (Lapgenic), Department of Biochemistry and Pharmacology, Federal University of Piauí, Teresina, Brazil.
Jazyk: angličtina
Zdroj: Journal of oncology [J Oncol] 2021 Dec 07; Vol. 2021, pp. 9031975. Date of Electronic Publication: 2021 Dec 07 (Print Publication: 2021).
DOI: 10.1155/2021/9031975
Abstrakt: Mimosa caesalpiniifolia (Fabaceae) is used by Brazilian people to treat hypertension, bronchitis, and skin infections. Herein, we evaluated the antiproliferative action of the dichloromethane fraction from M. caesalpiniifolia (DFMC) stem bark on murine tumor cells and the in vivo toxicogenetic profile. Initially, the cytotoxic activity of DFMC on primary cultures of Sarcoma 180 (S180) cells by Alamar Blue, trypan, and cytokinesis block micronucleus (CBMN) assays was assessed after 72 h of exposure, followed by the treatment of S180-bearing Swiss mice for 7 days, physiological investigations, and DNA/chromosomal damage. DFMC and betulinic acid revealed similar in vitro antiproliferative action on S180 cells and induced a reduction in viable cells, induced a reduction in viable cells and caused the emergence of bridges, buds, and morphological features of apoptosis and necrosis. S180-transplanted mice treated with DFMC (50 and 100 mg/kg/day), a betulinic acid-rich dichloromethane, showed for the first time in vivo tumor growth reduction (64.8 and 80.0%) and poorer peri- and intratumor quantities of vessels. Such antiproliferative action was associated with detectible side effects (loss of weight, reduction of spleen, lymphocytopenia, and neutrophilia and increasing of GOT and micronucleus in bone marrow), but preclinical general anticancer properties of the DFMC were not threatened by toxicological effects, and these biomedical discoveries validate the ethnopharmacological reputation of Mimosa species as emerging phytotherapy sources of lead molecules.
Competing Interests: The authors declare that there are no conflicts of interest regarding the publication of this paper.
(Copyright © 2021 Paulo Michel Pinheiro Ferreira et al.)
Databáze: MEDLINE
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