The role of dendritic cells in endometriosis: A systematic review.

Autor: Laginha PA; Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil. Electronic address: laginhap@hotmail.com., Arcoverde FVL; Serviço de Ginecologia, Hospital Universitario Materno Infantil (UFMA), R. Silva Jardim, s/n - Centro, São Luis, MA, 65021-000, Brazil. Electronic address: fernandaarcoverde@hotmail.com., Riccio LGC; Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil. Electronic address: luiza.riccio@gmail.com., Andres MP; Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil; Gynecologic Division, BP - A Beneficencia Portuguesa de São Paulo, R. Maestro Cardim, 769 - Bela Vista, São Paulo, SP, 01323-001, Brazil. Electronic address: marina.dpandres@gmail.com., Abrão MS; Disciplina de Ginecologia, Departamento de Obstetrícia e Ginecologia, Faculdade de Medicina FMUSP, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar, 255 - Cerqueira César, São Paulo, SP, 05403-000, Brazil; Gynecologic Division, BP - A Beneficencia Portuguesa de São Paulo, R. Maestro Cardim, 769 - Bela Vista, São Paulo, SP, 01323-001, Brazil. Electronic address: msabrao@mac.com.
Jazyk: angličtina
Zdroj: Journal of reproductive immunology [J Reprod Immunol] 2022 Feb; Vol. 149, pp. 103462. Date of Electronic Publication: 2021 Dec 09.
DOI: 10.1016/j.jri.2021.103462
Abstrakt: Endometriosis (EDT), a common estrogen-dependent inflammatory disorder, is characterized by endometrial-like tissue outside the uterus. While its pathogenesis is poorly understood, it is supposed that the immune system plays a role in its pathophysiology, and increased number of immune cells and changes in both cell-mediated and humoral immunity have been described. Dendritic cells (DCs) are antigen-presenting cells (APC) of the immune system that recognize, capture, and process complex antigens and present them to T cells, conferring them a unique ability as mediators between the innate and adaptive immune systems. This systematic review aims to enlighten possible disturbances (systemically and locally) of DCs in the development and progression of endometriosis. A search using the strategy: ("dendritic cells" AND "immunology" AND "endometriosis") in databases resulted in 490 citations; after applying inclusion and exclusion criteria, a total of 13 studies were assessed. The evaluated studies demonstrated that DCs are susceptible to pro-endometriotic changes which could inhibit immature DCs (imDCs) from their maturation and induce imDCs into a macrophage phenotype. In addition, the growth and vascularization of endometriosis requires the presence of endogenous DC, which infiltrate endometriotic lesions and enhance endothelial cell migration by secreting proangiogenic factors. Whereas DC maturation suppresses this response, imDC actively promote angiogenesis and growth, leading to a switch in their immunologic role from presenting antigens to support angiogenesis and EDT progression.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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