Cross-modal connectivity effects in age-related hearing loss.

Autor: Ponticorvo S; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy., Manara R; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; Department of Neuroscience, University of Padova, Padova, Italy., Cassandro E; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Canna A; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Napoli, Italy., Scarpa A; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Troisi D; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Cassandro C; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Cuoco S; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Cappiello A; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Pellecchia MT; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Salle FD; Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana, University of Salerno, Baronissi, Italy; University Hospital 'San Giovanni di Dio e Ruggi D'Aragona', Scuola Medica Salernitana, Salerno, Italy., Esposito F; Department of Advanced Medical and Surgical Sciences, University of Campania 'Luigi Vanvitelli', Napoli, Italy. Electronic address: fabrizio.esposito@unicampania.it.
Jazyk: angličtina
Zdroj: Neurobiology of aging [Neurobiol Aging] 2022 Mar; Vol. 111, pp. 1-13. Date of Electronic Publication: 2021 Nov 14.
DOI: 10.1016/j.neurobiolaging.2021.09.024
Abstrakt: Age-related sensorineural hearing loss (HL) leads to localized brain changes in the primary auditory cortex, long-range functional alterations, and is considered a risk factor for dementia. Nonhuman studies have repeatedly highlighted cross-modal brain plasticity in sensorial brain networks other than those primarily involved in the peripheral damage, thus in this study, the possible cortical alterations associated with HL have been analyzed using a whole-brain multimodal connectomic approach. Fifty-two HL and 30 normal hearing participants were examined in a 3T MRI study along with audiological and neurological assessments. Between-regions functional connectivity and whole-brain probabilistic tractography were calculated in a connectome-based manner and graph theory was used to obtain low-dimensional features for the analysis of brain connectivity at global and local levels. The HL condition was associated with a different functional organization of the visual subnetwork as revealed by a significant increase in global efficiency, density, and clustering coefficient. These functional effects were mirrored by similar (but more subtle) structural effects suggesting that a functional repurposing of visual cortical centers occurs to compensate for age-related loss of hearing abilities.
Competing Interests: Disclosure statement The authors have no actual or potential conflicts of interest.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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