Supramammillary regulation of locomotion and hippocampal activity.

Autor:	Farrell JS; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Lovett-Barron M; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Neurobiology Section, Division of Biological Sciences, University of California, San Diego, CA, USA., Klein PM; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Sparks FT; Department of Neuroscience, Columbia University, New York, NY, USA.; Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA., Gschwind T; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Ortiz AL; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Ahanonu B; Departments of Biology and Applied Physics, Stanford University, Stanford, CA, USA.; Department of Anatomy, University of California, San Francisco, CA, USA., Bradbury S; Department of Bioengineering, Stanford University, Stanford, CA, USA., Terada S; Department of Neuroscience, Columbia University, New York, NY, USA.; Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA., Oijala M; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Hwaun E; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Dudok B; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Szabo G; Department of Neurosurgery, Stanford University, Stanford, CA, USA., Schnitzer MJ; Departments of Biology and Applied Physics, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA., Deisseroth K; Department of Bioengineering, Stanford University, Stanford, CA, USA.; Howard Hughes Medical Institute, Stanford University, Stanford, CA, USA.; Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA., Losonczy A; Department of Neuroscience, Columbia University, New York, NY, USA.; Kavli Institute for Brain Sciences, Columbia University, New York, NY, USA.; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA., Soltesz I; Department of Neurosurgery, Stanford University, Stanford, CA, USA.
Jazyk:	angličtina
Zdroj:	Science (New York, N.Y.) [Science] 2021 Dec 17; Vol. 374 (6574), pp. 1492-1496. Date of Electronic Publication: 2021 Dec 16.
DOI:	10.1126/science.abh4272
Abstrakt:	Locomotor speed is a basic input used to calculate one’s position, but where this signal comes from is unclear. We identified neurons in the supramammillary nucleus (SuM) of the rodent hypothalamus that were highly correlated with future locomotor speed and reliably drove locomotion when activated. Robust locomotion control was specifically identified in Tac1 (substance P)–expressing (SuM Tac1+ ) neurons, the activation of which selectively controlled the activity of speed-modulated hippocampal neurons. By contrast, Tac1 -deficient (SuM Tac1− ) cells weakly regulated locomotion but potently controlled the spike timing of hippocampal neurons and were sufficient to entrain local network oscillations. These findings emphasize that the SuM not only regulates basic locomotor activity but also selectively shapes hippocampal neural activity in a manner that may support spatial navigation.
Databáze:	MEDLINE
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