Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia-reperfusion injury.
Autor: | Li S; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Chen J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Liu M; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Chen Y; Department of Cardiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China., Wu Y; Department of Infectious Diseases, Zhongshan Hospital, Fudan University, Shanghai, China., Li Q; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Ma T; Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China., Gao J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Xia Y; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China., Fan M; Department of Cardiology, Affiliated Hospital of Nantong University, Xisi Road 20, Nantong, Jiangsu, China., Chen A; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China., Lu D; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China.; National Clinical Research Center for Interventional Medicine, Shanghai, China., Su E; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Xu F; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China., Chen Z; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. chen.zhangwei@zs-hospital.sh.cn.; National Clinical Research Center for Interventional Medicine, Shanghai, China. chen.zhangwei@zs-hospital.sh.cn., Qian J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. qian.juying@zs-hospital.sh.cn.; National Clinical Research Center for Interventional Medicine, Shanghai, China. qian.juying@zs-hospital.sh.cn., Ge J; Department of Cardiology, Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. jbge@zs-hospital.sh.cn.; National Clinical Research Center for Interventional Medicine, Shanghai, China. jbge@zs-hospital.sh.cn. |
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Jazyk: | angličtina |
Zdroj: | Basic research in cardiology [Basic Res Cardiol] 2021 Dec 16; Vol. 116 (1), pp. 65. Date of Electronic Publication: 2021 Dec 16. |
DOI: | 10.1007/s00395-021-00905-4 |
Abstrakt: | Current evidence indicates that coronary microcirculation is a key target for protecting against cardiac ischemia-reperfusion (I/R) injury. Mitochondrial calcium uniporter (MCU) complex activation and mitochondrial calcium ([Ca 2+ ] (© 2021. The Author(s).) |
Databáze: | MEDLINE |
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