The development of an international childhood cancer hospital register database in 13 African countries. A project of the French African Pediatric Oncology Group (GFAOP).

Autor: Mallon B; GFAOP, Gustave Roussy Villejuif, France., Kaboré R; Centre Hospitalier Universitaire Yalgado Ouédraogo, Ouagadougou, Burkina Faso., Couitchere L; Hôpital de Treichville, Abidjan, Ivory Coast., Akonde FB; Unité d'oncologie pédiatrique, Hôpital Aristide Le Dantec, Dakar, Senegal., Lukamba R; Cliniques Universitaires de Lubumbashi (CUL) Democratic Republic of Congo (DRC)., Dackono TA; Service d'Oncologie Pédiatrie CHU Gabriel Touré de Bamako, Mali., Narison MLR; CHU JRA Antananarivo, Madagascar., Khattab M; Hôpital d'Enfants CHU Ibn Sina Rabat, Morocco., Pondy A; Centre Mère et Enfant de la Fondation Chantal Biya, Yaoundé, Cameroon., Fedhila Ben Ayed F; Hôpital d'Enfants Béchir Hamza de Tunis, Tunisia., Budiongo A; Cliniques Universitaires de Kinshasa, DRC., Guedenon K; Unité d'oncologie pédiatrique, CHU Sylvanus Olympio, Lomé, Togo., Oberlin O; GFAOP, Gustave Roussy Villejuif, France., Patte C; GFAOP, Gustave Roussy Villejuif, France.
Jazyk: angličtina
Zdroj: Pediatric blood & cancer [Pediatr Blood Cancer] 2022 Mar; Vol. 69 (3), pp. e29464. Date of Electronic Publication: 2021 Dec 16.
DOI: 10.1002/pbc.29464
Abstrakt: Background and Aim: The establishment of an international hospital-based register (HBR) for the French African Pediatric Oncology Group (GFAOP) was a necessary step in the group's clinical research program. With help from the Sanofi Espoir Foundation's "My Child Matters" program, the GFAOP resolved to develop an international HBR network to collect quality data on children attending the Pediatric Oncology Units (POUs).
Methods: All children entering POUs from January 2016 to December 2018 were registered using an online questionnaire. Data collection included information on diagnosis, disease stage, demographics, socioeconomic status, and outcome. An intensive training program was developed to improve both data quality and quantity.
Results: Among the 3348 children registered, 3230 had a suspected cancer, 681 were not confirmed. A diagnosis was confirmed on radiological, clinical, or histological examination for 2549 children including Burkitt lymphoma (516: 20%)-the most frequent diagnosis, Wilms' tumor (459: 18%), retinoblastoma (357: 14%), and acute lymphoblastic leukemia (345: 13%). Of these, 2187 children were treated. Early deaths, abandonment, economic difficulties, and lack of equipment were some of the reasons offered to explain the numbers of undiagnosed and untreated children. Vital status is known for 1994 children: 1187 died and 807 were alive, 551 of these with a follow-up > 12 months.
Conclusion: This work has provided reliable data on children attending the POUs, especially clarifying reasons and occasions for care rupture. The data will help to identify material, human resources, and staff training needs, to evaluate progress, and to encourage consideration of pediatric cancer in national cancer plans.
(© 2021 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.)
Databáze: MEDLINE
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