Etiologies of Childhood Hearing Impairment in Schools for the Deaf in Mali.

Autor:	Yalcouyé A; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali.; Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa., Traoré O; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali., Taméga A; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali., Maïga AB; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali., Kané F; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali., Oluwole OG; Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa., Guinto CO; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali.; Service de Neurologie, Centre Hospitalier Universitaire du Point 'G', Bamako, Mali., Kéita M; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali.; Service d'ORL, Centre Hospitalier Universitaire de Gabriel Touré, Bamako, Mali., Timbo SK; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali.; Service d'ORL, Centre Hospitalier Universitaire de Gabriel Touré, Bamako, Mali., DeKock C; Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa., Landouré G; Faculté de Médecine et d'Odondostomatologie, Université des Sciences, Techniques et Technologies de Bamako (USTTB), Bamako, Mali.; Service de Neurologie, Centre Hospitalier Universitaire du Point 'G', Bamako, Mali., Wonkam A; Division of Human Genetics, Department of Pathology, University of Cape Town, Cape Town, South Africa.; Department of Medicine, University of Cape Town, Cape Town, South Africa.
Jazyk:	angličtina
Zdroj:	Frontiers in pediatrics [Front Pediatr] 2021 Nov 29; Vol. 9, pp. 726776. Date of Electronic Publication: 2021 Nov 29 (Print Publication: 2021).
DOI:	10.3389/fped.2021.726776
Abstrakt:	Objectives: To identify the etiologies of hearing impairment (HI) in schools for students who are deaf and to use a systematic review to summarize reports on the etiologies and clinical and genetic features of HI in Mali. Methods: We included individuals with HI that started before the age of 15 years old. Patients were carefully evaluated under standard practices, and pure-tone audiometry was performed where possible. We then searched for articles published on HI in the Malian population from the databases' inception to March 30, 2020. Results: A total of 117 individuals from two schools for the deaf were included, and a male predominance (sex ratio 1.3; 65/52) was noted. HI was pre-lingual in 82.2% ( n = 117), and the median age at diagnosis was 12 years old. The etiologies were environmental in 59.4% (70/117), with meningitis being the leading cause (40%, 20/70), followed by cases with genetic suspicion (29.3%, 21/117). In 11.3% (8/117) of patients, no etiology was identified. Among cases with genetic suspicion, three were syndromic, including two cases of Waardenburg syndrome, while 15 individuals had non-syndromic HI. An autosomal recessive inheritance pattern was observed in 83.3% of families (15/18), and consanguinity was reported in 55.5% (10/18) of putative genetic cases. Conclusion: This study concludes that environmental factors are the leading causes of HI in Mali. However, genetic causes should be investigated, particularly in the context of a population with a high consanguinity rate. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Yalcouyé, Traoré, Taméga, Maïga, Kané, Oluwole, Guinto, Kéita, Timbo, DeKock, Landouré and Wonkam.)
Databáze:	MEDLINE
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