Immunoglobulin A (IgA) Nephropathy: A Clinicopathologic Study in a Tertiary Care Center in Saudi Arabia.

Autor:	Bokhary OA; Medicine, King Abdulaziz University, Jeddah, SAU., Alhozali HM; Nephrology, King Abdulaziz University Hospital, Jeddah, SAU., Alghamdi MK; Medicine, King Abdulaziz University, Jeddah, SAU., Abulfaraj AM; Medicine, King Abdulaziz University, Jeddah, SAU., Alkhallagi AS; Medicine, King Abdulaziz University, Jeddah, SAU., Aldharrab AS; Medicine, King Abdulaziz University, Jeddah, SAU., Alyahya FS; Medicine, King Abdulaziz University, Jeddah, SAU., Al Zahrani RA; Pathology, King Abdulaziz University, Jeddah, SAU.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Nov 10; Vol. 13 (11), pp. e19445. Date of Electronic Publication: 2021 Nov 10 (Print Publication: 2021).
DOI:	10.7759/cureus.19445
Abstrakt:	Background: Immunoglobulin A nephropathy (IgAN) is the most common primary aetiology of glomerulonephritis worldwide, and it is the most important type in terms of morbidity and mortality. IgAN involves the deposition of immune bodies in the mesangial cells of the kidney, which causes renal glomerular damage, haematuria, proteinuria, and various other symptoms. Previous studies have mainly focused on the East Asian population, with few studies conducted in Saudi Arabia, particularly in the western region. The diagnosis requires a biopsy, which should be examined by an expert and classified according to the Oxford classification system. Objectives: Analyze the clinical, pathological, and laboratory features of male and female patients diagnosed with IgAN at King Abdulaziz University Hospital (KAUH). Methods and Materials: This was a retrospective record review conducted at KAUH in Jeddah, Saudi Arabia between May-June 2021. The study included 18 patients diagnosed with IgAN by biopsy, and their clinical, laboratory and pathological data were evaluated and classified according to the Oxford classification system. Results: Demographic data revealed a male predominance of 66.7%. The most common pathological finding was mesangial proliferation, and the most common presentation was haematuria. For treatment options, corticosteroids were the most prescribed drugs. A significant relationship was found between IgAN with increased serum creatinine and male sex (P = 0.017). Additionally, a significant relationship was observed between decreased estimated glomerular filtration rate (eGFR) in IgAN and the male sex (P = 0.006). Conclusions: We found a difference in terms of pathological, clinical and laboratory presentations of IgAN between males and females. Men generally had worse kidney function at presentation and advanced Oxford classification in their kidney biopsies compared to women. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Bokhary et al.)
Databáze:	MEDLINE
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