Effects of "Bacuri" Seed Butter ( Platonia insignis Mart.) on Metabolic Parameters in Hamsters with Diet-Induced Hypercholesterolemia.

Autor: Lima GM; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Brito AKDS; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., de Farias LM; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Rodrigues LARL; Departamento de Nutrição, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Pereira CFC; Departamento de Morfologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Lima SKR; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil.; Departamento de Educação, Instituto Federal de Educação, Ciência e Tecnologia do Maranhão, CEP 65700-000, Bacabal, MA, Brazil., Frota KMG; Departamento de Nutrição, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Rizzo MDS; Departamento de Morfologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Nunes PHM; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Lucarini M; CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy., Durazzo A; CREA-Research Centre for Food and Nutrition, Via Ardeatina 546, 00178 Rome, Italy., Arcanjo DDR; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil., Martins MDCCE; Departamento de Biofísica e Fisiologia, Universidade Federal do Piauí, CEP 64049-550, Teresina, PI, Brazil.
Jazyk: angličtina
Zdroj: Evidence-based complementary and alternative medicine : eCAM [Evid Based Complement Alternat Med] 2021 Dec 06; Vol. 2021, pp. 5584965. Date of Electronic Publication: 2021 Dec 06 (Print Publication: 2021).
DOI: 10.1155/2021/5584965
Abstrakt: This study aimed to evaluate the effects of the treatment with bacuri seed butter (BB) on body weight, growth, body mass index, lipid profile, atherosclerotic indices, and liver function in dyslipidemic hamsters. Freshly weaned, male hamsters were divided into four groups: (1) normal group (NG)-maintained with standard chow (AIN-93G); (2) dyslipidemia group (DG)-maintained with hyperlipidemic chow (AIN-93G modified) throughout the follow-up period; (3) bacuri seed butter 25 mg/kg/day (BB-25); and (4) bacuri seed butter 50 mg/kg/day (BB-50). BB groups (25 and 50 mg/kg/day) were also maintained with hyperlipidemic chow throughout the follow-up period, and the treatment started after 21 days receiving a hyperlipidemic diet to induce hypercholesterolemia and maintained for 28 days. No significant differences in triglycerides and total cholesterol were observed for BB-25 and BB-50 groups when compared with NG and DG groups. On the contrary, BB-25 and BB-50 induced both increase of HDL-c (51.40 ± 1.69 and 51.00 ± 2.34, respectively) and decrease of LDL-c (103.80 ± 6.87 and 100.50 ± 3.95, respectively) when compared with DG (41.00 ± 2.94 and 132.70 ± 9.41, respectively). In addition, BB promoted a reduction in the risk of atherosclerotic disease by decreasing ( p < 0.05) the atherogenic index, coronary artery risk index, and LDL/CT ratio ( p < 0.05) and increasing HDL/CT ratio. On the contrary, no changes were observed in total cholesterol and triglyceride levels or in body weight, growth, body mass index, or liver function parameters. Thus, bacuri seed butter at doses of 25 and 50 mg/kg/day has positive repercussions on the lipid profile, more precisely on plasma HDL-c and LDL-c, and additionally promotes reduction in the risk of atherosclerosis in hamsters.
Competing Interests: The authors declare no conflicts of interest.
(Copyright © 2021 Geovanni de Morais Lima et al.)
Databáze: MEDLINE
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