Bloodstream infections due to Trichosporon species in paediatric patients: Results from the first national study from Turkey.

Autor: Akaslan Kara A; Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey. Electronic address: aybukeakaslan@hotmail.com., Çay Ü; Department of Pediatric Infectious Diseases, Cukurova University Faculty of Medicine, Adana, Turkey., Yalçınkaya R; Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey., Erdeniz EH; Department of Pediatric Infectious Diseases, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey., Tural Kara T; Department of Pediatric Infectious Diseases, Akdeniz University Faculty of Medicine, Antalya, Turkey., Özdemir H; Department of Pediatric Infectious Diseases, Ankara University Faculty of Medicine, Ankara, Turkey., Güner Özenen G; Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, İzmir, Turkey., Polat M; Department of Pediatric Infectious Diseases, Pamukkale University Faculty of Medicine, Denizli, Turkey., Gayretli Aydın ZG; Department of Pediatric Infectious Diseases, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey., Alkan G; Department of Pediatric Infectious Diseases, Selcuk University Faculty of Medicine, Konya, Turkey., Kepenekli E; Department of Pediatric Infectious Diseases, Marmara University Faculty of Medicine, Istanbul, Turkey., Gündeşlioğlu ÖÖ; Department of Pediatric Infectious Diseases, Cukurova University Faculty of Medicine, Adana, Turkey., Kıymet E; Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Birinci A; Department of Microbiology, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey., Kibar F; Department of Microbiology, Cukurova University Faculty of Medicine, Adana, Turkey., Böncüoğlu E; Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Şahbudak Bal Z; Department of Pediatric Infectious Diseases, Ege University Faculty of Medicine, İzmir, Turkey., Alabaz D; Department of Pediatric Infectious Diseases, Cukurova University Faculty of Medicine, Adana, Turkey., Çiftçi E; Department of Pediatric Infectious Diseases, Ankara University Faculty of Medicine, Ankara, Turkey., Tanır G; Department of Pediatric Infectious Diseases, Dr. Sami Ulus Children's Health and Diseases Training and Research Hospital, Ankara, Turkey., Bayram N; Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey., Cengiz AB; Department of Pediatric Infectious Diseases, Hacettepe University Faculty of Medicine, Ankara, Turkey., Devrim İ; Department of Pediatric Infectious Diseases, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Turkey.
Jazyk: angličtina
Zdroj: Journal de mycologie medicale [J Mycol Med] 2022 Mar; Vol. 32 (1), pp. 101229. Date of Electronic Publication: 2021 Nov 21.
DOI: 10.1016/j.mycmed.2021.101229
Abstrakt: Background: Invasive Trichosporon infections are rarely seen opportunistic fungal infections in children and mainly affect immunocompromised patients. This multicenter retrospective study has rewieved the characteristics, risk factors, treatment modalities and outcomes of bloodstream infections caused by Trichosporon species in children diagnosed over the past ten years in Turkey.
Methods: The study was performed with the participation of 12 of 55 hospitals invited from Turkey. In each center, the patients with bloodstream infections caused by Trichosporon spp. between January 2010 and December 2020 were retrospectively ascertained and the results were reported to the study coordinator by means of a simple case report. Data were collected on patient demographics, underlying condition(s), treatment of.infections caused by Trichosporon spp, and 7 and 30- day mortality rates.
Results: A total of 28 cases with fungemia caused by Trichosporon spp. were included in the study. The most common underlying disease was paediatric cancers (39.3%). T. asahii infections were detected in 78.5 % (n=22) of patients. A various spectrum of antifungal treatment regimens were used including intravenous amphotericin B monotherapy in 35.7%, intravenous amphotericin B and voriconazole combination in 32.1% and intravenous voriconazole monotherapy in 28.6% of the patients. The overall mortality rate was 28.5 %. The mortality rates were 12.5% in the voricanozole, 30% in the amphotericin B and 33.3% in combined voriconazole -amphotericin B arms CONCLUSIONS: Invasive Trichosporon infections with an important impact of patients quality of life are almost related to underlying diseases with an overall mortality rate of 28.5%. Voriconazole was found to be associated with lower mortality rates when compared with other treatment regimens.
Competing Interests: Declaration of Conflict of Interest No potential conflict of interest has been declared by the author(s). All authors have reviewed and approved the finalized version of the manuscript, and contributed significantly to the survey. No financial support was provided relevant to this article. The manuscript has not been previously published nor is it being considered for publication elsewhere
(Copyright © 2021 SFMM. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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