Purkinje cells translate subjective salience into readiness to act and choice performance.

Autor:	Bina L; Department of Neuroscience, Erasmus MC, Rotterdam 3000 CA, the Netherlands., Romano V; Department of Neuroscience, Erasmus MC, Rotterdam 3000 CA, the Netherlands., Hoogland TM; Department of Neuroscience, Erasmus MC, Rotterdam 3000 CA, the Netherlands; Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam 1105 BA, the Netherlands., Bosman LWJ; Department of Neuroscience, Erasmus MC, Rotterdam 3000 CA, the Netherlands. Electronic address: l.bosman@erasmusmc.nl., De Zeeuw CI; Department of Neuroscience, Erasmus MC, Rotterdam 3000 CA, the Netherlands; Netherlands Institute for Neuroscience, Royal Academy of Arts and Sciences, Amsterdam 1105 BA, the Netherlands. Electronic address: c.dezeeuw@erasmusmc.nl.
Jazyk:	angličtina
Zdroj:	Cell reports [Cell Rep] 2021 Dec 14; Vol. 37 (11), pp. 110116.
DOI:	10.1016/j.celrep.2021.110116
Abstrakt:	The brain selectively allocates attention from a continuous stream of sensory input. This process is typically attributed to computations in distinct regions of the forebrain and midbrain. Here, we explore whether cerebellar Purkinje cells encode information about the selection of sensory inputs and could thereby contribute to non-motor forms of learning. We show that complex spikes of individual Purkinje cells change the sensory modality they encode to reflect changes in the perceived salience of sensory input. Comparisons with mouse models deficient in cerebellar plasticity suggest that changes in complex spike activity instruct potentiation of Purkinje cells simple spike firing, which is required for efficient learning. Our findings suggest that during learning, climbing fibers do not directly guide motor output, but rather contribute to a general readiness to act via changes in simple spike activity, thereby bridging the sequence from non-motor to motor functions. Competing Interests: Declaration of interests The authors declare no competing interests. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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