Ultrasound modulation of macaque prefrontal cortex selectively alters credit assignment-related activity and behavior.

Autor: Folloni D; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK., Fouragnan E; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK.; School of Psychology, University of Plymouth, Plymouth, UK., Wittmann MK; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK., Roumazeilles L; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK., Tankelevitch L; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK., Verhagen L; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK.; Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen, Nijmegen, 6525 HR, Netherlands., Attali D; Physics for Medicine Paris, ESPCI Paris, INSERM, CNRS, PSL Research University, Paris, France.; GHU PARIS Psychiatrie and Neurosciences, site Sainte-Anne, Service Hospitalo-Universitaire, Pôle Hospitalo-Universitaire, Paris 15, F-75014 Paris, France.; Université de Paris, F-75005 Paris, France., Aubry JF; Physics for Medicine Paris, ESPCI Paris, INSERM, CNRS, PSL Research University, Paris, France., Sallet J; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK.; Université Lyon 1, Inserm, Stem Cell and Brain Research Institute U1208, 18 Avenue Doyen Lepine, 69500 Bron, France., Rushworth MFS; Wellcome Centre for Integrative Neuroimaging (WIN), Department of Experimental Psychology, Tinsley Building, Mansfield Road, Oxford OX1 3TA, University of Oxford, Oxford, UK.
Jazyk: angličtina
Zdroj: Science advances [Sci Adv] 2021 Dec 17; Vol. 7 (51), pp. eabg7700. Date of Electronic Publication: 2021 Dec 15.
DOI: 10.1126/sciadv.abg7700
Abstrakt: Credit assignment is the association of specific instances of reward to the specific events, such as a particular choice, that caused them. Without credit assignment, choice values reflect an approximate estimate of how good the environment was when the choice was made—the global reward state—rather than exactly which outcome the choice caused. Combined transcranial ultrasound stimulation (TUS) and functional magnetic resonance imaging in macaques demonstrate credit assignment–related activity in prefrontal area 47/12o, and when this signal was disrupted with TUS, choice value representations across the brain were impaired. As a consequence, behavior was no longer guided by choice value, and decision-making was poorer. By contrast, global reward state–related activity in the adjacent anterior insula remained intact and determined decision-making after prefrontal disruption.
Databáze: MEDLINE