HEALTH-RELATED QUALITY OF LIFE IN ADOLESCENTS AND YOUNG ADULTS WITH INFLAMMATORY BOWEL DISEASE IS ASSOCIATED WITH REDUCTION IN SCHOOL AND WORK PRODUCTIVITY RATHER THAN PHYSICAL IMPAIRMENT: A MULTIDISCIPLINARY STUDY.

Autor:	Oba J; Faculdade de Medicina da Universidade de São Paulo, Gastroenterologia Pediátrica, São Paulo, SP, Brasil., Sobrado CW; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Disciplina de Coloproctologia, São Paulo, SP, Brasil.; Faculdade de Medicina da Universidade de São Paulo, Divisão de Gastroenterologia e Hepatologia Clínica, São Paulo, SP, Brasil., Damião AOMC; Faculdade de Medicina da Universidade de São Paulo, Divisão de Gastroenterologia e Hepatologia Clínica, São Paulo, SP, Brasil., Azevedo M; Faculdade de Medicina da Universidade de São Paulo, Divisão de Gastroenterologia e Hepatologia Clínica, São Paulo, SP, Brasil., Carlos A; Faculdade de Medicina da Universidade de São Paulo, Divisão de Gastroenterologia e Hepatologia Clínica, São Paulo, SP, Brasil., Queiroz N; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Disciplina de Coloproctologia, São Paulo, SP, Brasil., Len CA; Universidade Federal de São Paulo, Reumatologia Pediátrica, São Paulo, SP, Brasil., Toma RK; Faculdade de Medicina da Universidade de São Paulo, Gastroenterologia Pediátrica, São Paulo, SP, Brasil., Deboni M; Faculdade de Medicina da Universidade de São Paulo, Gastroenterologia Pediátrica, São Paulo, SP, Brasil., Ozaki MJ; Faculdade de Medicina da Universidade de São Paulo, Gastroenterologia Pediátrica, São Paulo, SP, Brasil., Carrilho FJ; Faculdade de Medicina da Universidade de São Paulo, Divisão de Gastroenterologia e Hepatologia Clínica, São Paulo, SP, Brasil., Nahas S; Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo, Disciplina de Coloproctologia, São Paulo, SP, Brasil., Silva CA; Universidade de São Paulo, Instituto da Criança e do Adolescente, São Paulo, SP, Brasil.
Jazyk:	angličtina
Zdroj:	Arquivos de gastroenterologia [Arq Gastroenterol] 2021 Oct-Dec; Vol. 58 (4), pp. 541-547.
DOI:	10.1590/S0004-2803.202100000-96
Abstrakt:	Background: Inflammatory bowel diseases (IBD), comprising Crohn's disease and ulcerative colitis, are chronic inflammatory diseases of the gastrointestinal tract that often have their onset among adolescents and young adults (AYA). IBD are characterized by episodes of active disease interspersed with periods of remission, and its activity is inversely correlated with health-related quality of life (HRQL). Objective: This study aimed to determine whether AYA in remission or with low IBD activity would exhibit HRQL similar to that of age-matched healthy individuals, and whether demographic and disease factors could affect HRQL using a 'patient-reported outcome' instrument. Methods: This study enrolled only AYA with IBD, with low activity. This research included five multidisciplinary clinics of two academic hospitals: Paediatric Gastroenterology, Gastroenterology, Coloproctology, Paediatric Rheumatology and Adolescent divisions, São Paulo, Brazil. A total of 59 AYA with IBD (age, 13-25 years) and 60 healthy AYA (age, 13-25 years) completed the Pediatric Quality of Life Inventory 4.0 and 36-Item Short-Form Health Survey questionnaires and the visual analogue scale (VAS) for pain. Demographic data, extra-intestinal manifestations, treatment, and outcomes regarding CD and UC were evaluated. Results: AYA with IBD and healthy controls were similar with respect to median ages (18.63 [13.14-25.80] years vs 20.5 [13.68-25.84] years, P=0.598), proportion of female sex (42% vs 38%, P=0.654), and percentage of upper middle/middle Brazilian socioeconomic classes (94% vs 97%, P=0.596). The school/work score was significantly lower in AYA with IBD than in healthy controls (70 [10-100] vs 75 [5-100], P=0.037). The 'general health-perception' score was significantly lower in AYA with IBD than in healthy controls (50 [10-80] vs 0 [25-90], P=0.0002). The median VAS, FACES pain rating scale, and total VAS scores were similar between the two groups (2 [0-10] vs 3 [0-9], P=0.214). No association between HRQL and clinical and demographic parameters was identified among IBD patients. Conclusion: AYA with low IBD activity reported poor HRQL in school/work and general health perception domains, which highlights a disability criterion in this vulnerable population.
Databáze:	MEDLINE
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