Association of Intestinal Microbial Dysbiosis With Chronic Obstructive Pulmonary Disease.

Autor:	Ananya FN; Respiratory Medicine, Dhaka Medical College and Hospital, Dhaka, BGD.; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Ahammed MR; Cardiology, National Institute of Cardiovascular Diseases, Dhaka, BGD.; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Fahem MM; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Kafle S; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Viswanathan M; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Desai D; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Akku R; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Khan F; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Hernandez TE; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Bala SK; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Gulati S; Research & Academic Affairs, Larkin Community Hospital, South Miami, USA., Martin N; Internal Medicine, Larkin Community Hospital, South Miami, USA., Yatzkan GD; Pulmonary Medicine, Larkin University School of Medicine, Miami, USA., Pérez-Fernández J; Intensive Care Solutions, Larkin University School of Medicine, Miami, USA.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2021 Nov 07; Vol. 13 (11), pp. e19343. Date of Electronic Publication: 2021 Nov 07 (Print Publication: 2021).
DOI:	10.7759/cureus.19343
Abstrakt:	Normal gut flora plays various beneficial roles for the human body, including the protection against inflammatory states and mucosal viral infections. It also influences the immune system of the body. The metabolites produced by the gut bacteria control local and other systemic organs' immune functions like the lungs and brain, playing a role in their response to acute and chronic illnesses. Probiotics have shown beneficial effects on lung health. On the contrary, dysbiosis is associated with several diseases, including asthma, chronic bronchitis, emphysema, allergies, and other acute viral infections. By altering the diet of patients with respiratory diseases like patients with chronic obstructive pulmonary diseases (COPD), we may be able to mitigate their conditions. This literature review aims to discuss the mechanisms altering the gastrointestinal flora, the pathophysiology of gut and lung axis, the role of diet in gut microbe health, and the association of COPD with gut dysbiosis and peptic ulcer disease (PUD). We have extracted the data from PubMed and Google Scholar, consisting of review articles, case-control studies, and animal studies. The studies showed an association between gut microbes and different lung diseases. It is found that gut dysbiosis not only disrupts intestinal immunity but may also facilitate the development of COPD. Present studies also show an increased seroprevalence of Helicobacter pylori in patients with COPD. The strategies that can improve lung functions, especially in COPD patients, include prebiotics and probiotic supplementation to a diet more balanced than the current average American diet. Competing Interests: The authors have declared that no competing interests exist. (Copyright © 2021, Ananya et al.)
Databáze:	MEDLINE
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