The effect of Propofol versus Dexmedetomidine as anesthetic agents for oocyte pick-up on in vitro fertilization (IVF) outcomes.

Autor: Budak Ö; Department of Histology and Embryology and Artificial Reproductive Techniques, Faculty of Medicine, Sakarya University, Sakarya, Turkey., Bostancı MS; Department of Obstetrics and Gynecology and Artificial Reproductive Techniques, Faculty of Medicine, Sakarya University, Sakarya, Turkey. msbostanci@sakarya.edu.tr., Tuna A; Department of Anesthesiology and Reanimation, Faculty of Medicine, Sakarya University, Sakarya, Turkey., Toprak V; Department of Obstetrics and Gynecology, Private Tatvan Can Hospital, Bitlis, Turkey., Çakiroğlu H; Medical and Experimental Research Center, Faculty of Medicine, Sakarya University, Sakarya, Turkey., Gök K; Department of Obstetrics and Gynecology, Faculty of Medicine, Sakarya University, Sakarya, Turkey.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2021 Dec 14; Vol. 11 (1), pp. 23922. Date of Electronic Publication: 2021 Dec 14.
DOI: 10.1038/s41598-021-03177-z
Abstrakt: This study aimed to evaluate the effects of propofol and dexmedetomidine over different timescales on the IVF outcomes for transvaginal oocyte retrieval (TVOR). Twenty-four rats included in the study were divided into two main groups and three subgroups were subjected to the ovulation induction process. Group 1 was administered propofol (100 mg/kg i.v.) and group 2 were administered dexmedetomidine (25 µg/kg i.p.) The oviduct collection procedure was completed within 15 min for subgroup Pro15min, Dex15min (n = 4), within 16 to 30 min for subgroup Pro30min, Dex30min (n = 4) and within 31 to 60 min for subgroup Pro60min, Dex60min (n = 4) after euthanasia. The total number of oocytes was counted. After in vitro fertilization, the number and quality of embryos were evaluated. The number of pups born were evaluated after embryo transfer. The embryo number, quality and pup count decreased as the administration time for propofol increased (p < 0.05). No statistically significant difference was found between the dexmedetomidine subgroups for embryo number, quality and pup count(p > 0.05). As the exposure time to propofol increased, the number and quality of embryos obtained, and the pup count, decreased. The use of dexmedetomidine had no negative impacts on the number of embryos, their quality or the number of pups.
(© 2021. The Author(s).)
Databáze: MEDLINE
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