Heparin Binding Protein for the Early Diagnosis and Prognosis of Sepsis in the Emergency Department: The Prompt Multicenter Study.

Autor:	Katsaros K; Department of Surgery, Nafplion General Hospital, Nafplion, Greece., Renieris G; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Safarika A; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Adami EM; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Gkavogianni T; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Giannikopoulos G; Department of Internal Medicine, Syros General Hospital, Ermoupolis, Syros, Greece., Solomonidi N; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Halvatzis S; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Koutelidakis IM; Second Department of Surgery, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tsokos N; Department of Internal Medicine, Chalkida General Hospital, Chalkida, Greece., Tritzali M; Department of Internal Medicine, Syros General Hospital, Ermoupolis, Syros, Greece., Koutoukas P; Department of Internal Medicine, Sparti General Hospital, Sparti, Greece., Avgoustou C; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece., Vasishta A; Ashyana, Dundee DD53PD, Scotland., Giamarellos-Bourboulis EJ; Fourth Department of Internal Medicine, National and Kapodistrian University of Athens, Medical School, Athens, Greece.
Jazyk:	angličtina
Zdroj:	Shock (Augusta, Ga.) [Shock] 2022 Apr 01; Vol. 57 (4), pp. 518-525.
DOI:	10.1097/SHK.0000000000001900
Abstrakt:	Background: The validation of new biomarkers for the diagnosis and risk stratification of patients with sepsis at an early point is essential for successful treatment. Recent publications prompted us to investigate of heparin binding protein (HBP) for the emergency department (ED) admissions. Materials and Methods: In this multicenter, cross-sectional study, HBP and procalcitonin (PCT) were measured within the first hour upon admission to the ED in plasma samples of 371 patients with signs of infection. Patients were classified into non-sepsis and sepsis by the Sepsis-3 definitions and were followed up for outcome. Results: HBP was significantly higher in patients with sepsis and was positively correlated to PCT and C-reactive protein, absolute neutrophil and monocyte counts, creatinine, bilirubin and lactate. Sensitivity, specificity, positive predictive value, and negative predictive value of HBP more than 19.8 ng/mL for the diagnosis of sepsis was 66.3%, 44.9%, 49.3%, and 62.2%, respectively; and for prediction of early death was 100%, 41.0%, 4.5%, and 100%, respectively. Single HBP and PCT could not predict 28-day mortality; this was performed with sensitivity, specificity, positive predictive value, and negative predictive value 44.8%, 81.8%, 17.3%, and 94.6% when used in combination. Conclusion: Admission HBP can be used as a tool for the early diagnosis of sepsis and for the risk of early death in the ED. Competing Interests: The other authors report no conflicts of interest. (Copyright © 2021 by the Shock Society.)
Databáze:	MEDLINE
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