Hematologic parameters as a predictor of myometrial and cervical invasion in endometrial cancer.

Autor:	Bilir F; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey - drflzyldz@hotmail.com., Arioz DT; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Vatansever N; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Filiz T; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey., Elaziz B; Department of Gynecologic Oncology, Afyonkarahisar Health Science University, Afyonkarahisar, Turkey.
Jazyk:	angličtina
Zdroj:	Minerva obstetrics and gynecology [Minerva Obstet Gynecol] 2021 Dec; Vol. 73 (6), pp. 770-775.
DOI:	10.23736/S2724-606X.21.04715-1
Abstrakt:	Background: Despite significant improvements in molecular biology for uterine cancer, we did not have specific peripheral blood biomarkers for clinical usage such as prognostic or predictive outcomes of disease in the last decade. Methods: A retrospective endometrial cancer database was collected from a tertiary gynecologic cancer center. The cohort included only endometrioid type uterine cancer. Subsequently, we investigated the relationship between preoperative hematologic parameters and pathologic findings. Results: In this study, 191 non-metastatic endometrial cancer (median age was 61 years, ranging from 41 to 86 years) were analyzed. Lymphocyte-to-monocyte ratio (LMR) was significantly different between the FIGO stage I and II (4.48 vs. 3.88, P=0.004). Platelet-to-lymphocyte (PLR) was significantly higher in FIGO stage III than stage I, and LMR was significantly decreased by each FIGO stage. LMR values significantly decreased with a depth of myometrial invasion. PLR and eosinophil-to-lymphocyte ratio (ELR) values were significantly higher in patients with cervical invasion compared to those without invasion, 287 vs. 144, P=0.005, 10.3 vs. 6, P=0.022, respectively. Conclusions: This study revealed that low-LMR levels and high-PLR with ELR levels correlated with myometrial and cervical invasion, respectively. These findings can explain why hematologic parameters have an impact on oncologic outcomes.
Databáze:	MEDLINE
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