High-intensity interval training attenuates the effects caused by arterial hypertension in the ventral prostate.

Autor: Correia RR; Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil., Batista VRG; Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil., Veras ASC; Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil.; Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil., Tavares MEA; Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil.; Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil., Souza FLA; Postgraduate Animal Science Program, University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil., Pacagnelli FL; Postgraduate Animal Science Program, University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil., Campos DHS; Department of Clinical Medicine, Botucatu Medical School, São Paulo State University, Botucatu, São Paulo, Brazil., Giometti IC; Department of Reproduction, Faculty of Agricultural Sciences, University of Western São Paulo (UNOESTE), Presidente Prudente, São Paulo, Brazil., Teixeira GR; Department of Physical Education, Experimental Laboratory of Exercise Biology (LEBioEx), School of Technology and Sciences, São Paulo State University (UNESP), Presidente Prudente, São Paulo, Brazil.; Multicentric Program of Postgraduate in Physiological Sciences, School of Dentistry of Araçatuba, São Paulo State University (UNESP), Araçatuba, São Paulo, Brazil.
Jazyk: angličtina
Zdroj: The Prostate [Prostate] 2022 Feb; Vol. 82 (3), pp. 373-387. Date of Electronic Publication: 2021 Dec 14.
DOI: 10.1002/pros.24285
Abstrakt: Background: The prostatic effects induced by arterial hypertension is very controversial and its mechanism is unclear. High-intensity interval training (HIIT) is an exercise considered to be hypotensive. The objective of this work was to investigate the molecular, biochemical, and morphological effects of 8 weeks of HIIT in the prostatic tissue of spontaneously hypertensive rats (SHR).
Methods: Twenty male SHR rats, 51.4 weeks old, were used. The SHR animals were divided into two groups: spontaneously sedentary hypertensive and spontaneously hypertensive submitted to HIIT. We analyze androgens receptor and glucocorticoid receptors in the prostate. Still, we verify effects of the hypertension and HIIT on the physiopathology prostatic, for immunohistochemistry investigated BCL-2, BAX, IGF-1, FAS/CD95, data's inflammatory tumour necrosis factor α, nuclear factor kappa B and interleukin (IL)-6, anti-inflammatory IL-10. The echocardiographic evaluation was performed at the baseline and after the training period.
Results: Arterial hypertension promote high prostatic intraepithelial neoplasia incidence in the prostate, increases IGF-1, BCL-2 (p < 0.05), and inflammatory proteins (p < 0.05). Eight weeks of HIIT training reduced the arterial pressure and increase the concentration of tissue collagen and intracellular glycogen and showed a higher expression of BAX, FAS/CD95, and IL-10 proteins (p < 0.05), coinciding with a lower incidence of lesions and lower prostate weight (p < 0.05) and reduction of the BCL-2 and IGF-1.
Conclusion: Our data suggested that arterial hypertension suppressed apoptosis and increased damage prostatic. On other hand, HIIT promotes morphology and function improves in the prostatic environment, inhibited inflammation, and increased apoptosis.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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