The atomic portrait of SARS-CoV-2 as captured by cryo-electron microscopy.

Autor: Fertig TE; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania., Chitoiu L; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Terinte-Balcan G; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Peteu VE; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Marta D; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania., Gherghiceanu M; Ultrastructural Pathology and Bioimaging Lab, Victor Babeș National Institute of Pathology, Bucharest, Romania.; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania.
Jazyk: angličtina
Zdroj: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Jan; Vol. 26 (1), pp. 25-34. Date of Electronic Publication: 2021 Dec 14.
DOI: 10.1111/jcmm.17103
Abstrakt: Transmission electron microscopy has historically been indispensable for virology research, as it offers unique insight into virus function. In the past decade, as cryo-electron microscopy (cryo-EM) has matured and become more accessible, we have been able to peer into the structure of viruses at the atomic level and understand how they interact with the host cell, with drugs or with antibodies. Perhaps, there was no time in recent history where cryo-EM was more needed, as SARS-CoV-2 has spread around the globe, causing millions of deaths and almost unquantifiable economic devastation. In this concise review, we aim to mark the most important contributions of cryo-EM to understanding the structure and function of SARS-CoV-2 proteins, from surface spikes to the virus core and from virus-receptor interactions to antibody binding.
(© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
Databáze: MEDLINE
Externí odkaz: