Longitudinal systolic dysfunction in hypertensive cardiomyopathy with normal ejection fraction.

Autor: Salas-Pacheco JL; Cardiology Department, Centenario Hospital Miguel Hidalgo, Ferrocarril avenue, Alameda, Aguascalientes, México., Lomelí-Sánchez O; Cardiology Department, Antiguo Hospital Civil de Guadalajara Fray Antonio Alcalde, El Retiro, Guadalajara, México., Baltazar-González O; Cardiology Department, Hospital Civil Juan I. Menchaca, Salvador Quevedo, Independencia, Guadalajara, México., Soto ME; Immunology Department, Instituto Nacional de Cardiología Ignacio Chávez, Juan Badiano 1, Sección XVI, Tlalpan, México City, México.
Jazyk: angličtina
Zdroj: Echocardiography (Mount Kisco, N.Y.) [Echocardiography] 2022 Jan; Vol. 39 (1), pp. 46-53. Date of Electronic Publication: 2021 Dec 13.
DOI: 10.1111/echo.15267
Abstrakt: Background: The left ventricle (LV) journey in their transition from hypertrophy to heart failure is marked by many subcellular events partially understood yet. The moment in which the structural abnormalities reach the umbral to induce myocardial dysfunction remains elusive.
Aims: To evaluate the anatomic-functional relationship between LV wall thickness and longitudinal systolic dysfunction.
Material and Methods: We prospectively performed clinical assessment and transthoracic echocardiogram on healthy individuals and hypertensive patients with left ventricle ejection fraction (LVEF) ≥50% and absence of heart failure symptoms.
Results: A total of 226 patients and 101 healthy individuals were recruited. The distribution for sex was similar between groups. The mean age was 67±13 years old in the patients, and 44% had concentric LV hypertrophy. LVEF was identical in both groups (63±6%); in contrast, global longitudinal strain (GLS) (-18.8±2.5% vs -20.4±2%) and mitral annulus plane systolic excursion (MAPSE) (13.8±2.8 vs 15.5±2 mm) were lower. ROC curve optimally classified decreased GLS with LV septum thickness ≥13 mm and decreased MAPSE with thickness ≥14 mm. Multivariable logistic regression found that LV septum thickness is the only variable associated with longitudinal systolic dysfunction (OR = 1.1, CI 95%  =   1.05 - 1.15, P = 0.001, R squared = .38).
Discussion: A progressive increase in LV wall thickness due to myocyte hypertrophy and interstitial expansion is associated with LV systolic longitudinal dysfunction.
Conclusions: Patients with moderate or severe ventricular hypertrophy (septum ≥13 mm) had longitudinal systolic dysfunction, GLS decreases with minor structural change than MAPSE, and LVEF is insensitive in detecting longitudinal myocardial dysfunction in patients with hypertension.
(© 2021 Wiley Periodicals LLC.)
Databáze: MEDLINE
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