[Normal organoids and their applications in cancer research].

Autor:	Delom F; ARTiSt group, Univ Bordeaux, Inserm, Institut Bergonié, ACTION, U1218, 33000 Bordeaux, France., Le Morvan V; ARTiSt group, Univ Bordeaux, Inserm, Institut Bergonié, ACTION, U1218, 33000 Bordeaux, France., Robert J; ARTiSt group, Univ Bordeaux, Inserm, Institut Bergonié, ACTION, U1218, 33000 Bordeaux, France., Fessart D; ARTiSt group, Univ Bordeaux, Inserm, Institut Bergonié, ACTION, U1218, 33000 Bordeaux, France; Inserm U1242, 'chemistry, oncogenesis stress signaling', université Rennes 1, 35000 Rennes, France; Centre de lutte contre le cancer Eugène Marquis, 35000 Rennes, France. Electronic address: delphine.fessart@inserm.fr.
Jazyk:	francouzština
Zdroj:	Bulletin du cancer [Bull Cancer] 2022 Jan; Vol. 109 (1), pp. 58-64. Date of Electronic Publication: 2021 Dec 10.
DOI:	10.1016/j.bulcan.2021.11.004
Abstrakt:	Three-dimensional (3D) culture of organoids from primary cells (wild type) or tumoroids from tumor cells, is used to study the physiological mechanisms in vivo, in order to model normal or tumor tissues more accurately than conventional two-dimensional (2D) culture. The features of this 3D culture, such as the three-dimensional structure, the self-renewal capacity and differentiation are preserved and appropriate to cancer study since their cellular characteristics are very similar to in vivo models. Here, we summarize the recent advances in the rapidly evolving field of organoids and their applications to cancer biology, clinical research and personalized medicine. (Copyright © 2021 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.)
Databáze:	MEDLINE
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