| Autor: |
Gilberto DB; Safety Assessment Laboratory Animal Resources, Company, Kenilworth, New Jersey., Michener MS; Safety Assessment Laboratory Animal Resources, Company, Kenilworth, New Jersey., Smith BE; Safety Assessment Laboratory Animal Resources, Company, Kenilworth, New Jersey., Szczerba PJ; Clinical Pathology, Company, Kenilworth, New Jersey., Holahan MA; Translational Imaging Biomarkers, Merck, Company, Kenilworth, New Jersey., Gray TL; Safety Assessment Laboratory Animal Resources, Company, Kenilworth, New Jersey., Motzel SL; Safety Assessment Laboratory Animal Resources, Company, Kenilworth, New Jersey. |
| Abstrakt: |
More than 20 y ago, we developed an animal model for chronic and continuous collection of cerebrospinal fluid (CSF) from conscious rhesus macaques. Since our previous publication in 2003, we have successfully implanted 168 rhesus macaques using this approach. Our experience enables us to provide up-to-date information regarding the model, including refine- ments to our implant design, reductions in maintenance, and new procedures for dealing with contamination. The results of our experiences have reduced the number of surgeries required and helped to increase the longevity of the implant, with some functioning for more than 18 y. Building on our success in rhesus macaques, we attempted to develop similar animal models in the African green monkeys and dogs but have been unable to develop reliable chronic models for CSF collection in these species. |
