Atypical Prolonged Viral Shedding With Intra-Host SARS-CoV-2 Evolution in a Mildly Affected Symptomatic Patient.

Autor:	Cunha MDP; Scientific Platform Pasteur-USP, São Paulo, Brazil., Vilela APP; Scientific Platform Pasteur-USP, São Paulo, Brazil., Molina CV; Scientific Platform Pasteur-USP, São Paulo, Brazil., Acuña SM; Scientific Platform Pasteur-USP, São Paulo, Brazil., Muxel SM; Scientific Platform Pasteur-USP, São Paulo, Brazil.; Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Barroso VM; Scientific Platform Pasteur-USP, São Paulo, Brazil.; Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Baroni S; Scientific Platform Pasteur-USP, São Paulo, Brazil., Gomes de Oliveira L; Scientific Platform Pasteur-USP, São Paulo, Brazil., Angelo YS; Scientific Platform Pasteur-USP, São Paulo, Brazil., Peron JPS; Scientific Platform Pasteur-USP, São Paulo, Brazil.; Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Góes LGB; Scientific Platform Pasteur-USP, São Paulo, Brazil.; Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Campos ACA; Scientific Platform Pasteur-USP, São Paulo, Brazil., Minóprio P; Scientific Platform Pasteur-USP, São Paulo, Brazil.; Institut Pasteur, Paris, France.
Jazyk:	angličtina
Zdroj:	Frontiers in medicine [Front Med (Lausanne)] 2021 Nov 26; Vol. 8, pp. 760170. Date of Electronic Publication: 2021 Nov 26 (Print Publication: 2021).
DOI:	10.3389/fmed.2021.760170
Abstrakt:	The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is caused by a respiratory virus with a wide range of manifestations, varying from asymptomatic to fatal cases, with a generally short outcome. However, some individuals present long-term viral shedding. We monitored 38 individuals who were mildly affected by the SARS-CoV-2 infection. Out of the total studied population, three (7.9%) showed atypical events regarding the duration of positivity for viral RNA detection. In one of these atypical cases, a previously HIV-positive male patient presented a SARS-CoV-2 RNA shedding and subgenomic RNA (sgRNA) detected from the upper respiratory tract, respectively, for 232 and 224 days after the onset of the symptoms. The SARS-CoV-2 B.1.1.28 lineage, one of the most prevalent in Brazil in 2020, was identified in this patient in three serial samples. Interestingly, the genomic analyses performed throughout the infectious process showed an increase in the genetic diversity of the B.1.1.28 lineage within the host itself, with viral clearance occurring naturally, without any intervention measures to control the infection. Contrasting widely spread current knowledge, our results indicate that potentially infectious SARS-CoV-2 virus might be shed by much longer periods by some infected patients. This data call attention to better adapted non-pharmacological measures and clinical discharge of patients aiming at preventing the spread of SARS-CoV-2 to the population. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Cunha, Vilela, Molina, Acuña, Muxel, Barroso, Baroni, Gomes de Oliveira, Angelo, Peron, Góes, Campos and Minóprio.)
Databáze:	MEDLINE
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