Systematisation of biological protectors for managing the metabolic syndrome development.

Autor: Benberin VV; Administrative Department, Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan., Sibagatova AS; Sector оf Clinical Research, Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan., Nagimtayeva AA; Gerontology Centre, Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan., Akhmetova KM; Gerontology Centre, Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan., Voshchenkova TA; Gerontology Centre, Medical Centre Hospital of President's Affairs Administration of the Republic of Kazakhstan, 010000, 80 Mangilik El Ave., Nur-Sultan, Republic of Kazakhstan.
Jazyk: angličtina
Zdroj: Journal of diabetes and metabolic disorders [J Diabetes Metab Disord] 2021 Aug 25; Vol. 20 (2), pp. 1449-1454. Date of Electronic Publication: 2021 Aug 25 (Print Publication: 2021).
DOI: 10.1007/s40200-021-00883-3
Abstrakt: Background: Metabolic syndrome (MS) is becoming a major health risk in the world. Disorders of homeostasis are a trigger for MS and subsequent cardiometabolic diseases (CMDs). Its physiological role can be supported by biological protectors (BP). The purpose of this study is to develop a BP system for managing the MS development.
Methods: Within the framework of the case-control study, 3000 participants aged 20-60 years formed 2 groups: the main group and the control group.
Results: The study compared traditional markers of oxidative stress, chronic inflammation, and insulin resistance, which reflect the state of homeostasis. The BP system, proposed based on the concept of maintaining homeostasis, offers the following points for investigating the possibilities of therapeutic intervention: confronting dysregulation of homeostasis, resisting chronic inflammation and oxidative stress, resisting the consequences of disturbed homeostasis. This approach not only contributed to the understanding of general biological processes, but also provided a targeted search and development of BP to maintain the stability of homeostasis with MS.
Conclusions: The study results provided insight into new opportunities in the MS management.
Competing Interests: Conflict of interestThere are no conflicts of interest to declare.
(© Springer Nature Switzerland AG 2021.)
Databáze: MEDLINE
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