Reactive Oxygen Species: Do They Play a Role in Adaptive Immunity?
| Autor: | Bassoy EY; International Society of Liver Surgeons (ISLS), Cankaya Ankara, Turkey.; Departments of Immunology and Cancer Biology, College of Medicine and Science, Mayo Clinic, Scottsdale, AZ, United States., Walch M; Faculty of Science and Medicine, Department of Oncology, Microbiology and Immunology, Anatomy Unit, University of Fribourg, Fribourg, Switzerland., Martinvalet D; Department of Biomedical Sciences, University of Padua, Padova, Italy.; Veneto Institute of Molecular Medicine, Padova, Italy. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in immunology [Front Immunol] 2021 Nov 22; Vol. 12, pp. 755856. Date of Electronic Publication: 2021 Nov 22 (Print Publication: 2021). |
| DOI: | 10.3389/fimmu.2021.755856 |
| Abstrakt: | The immune system protects the host from a plethora of microorganisms and toxins through its unique ability to distinguish self from non-self. To perform this delicate but essential task, the immune system relies on two lines of defense. The innate immune system, which is by nature fast acting, represents the first line of defense. It involves anatomical barriers, physiological factors as well as a subset of haematopoietically-derived cells generically call leukocytes. Activation of the innate immune response leads to a state of inflammation that serves to both warn about and combat the ongoing infection and delivers the antigenic information of the invading pathogens to initiate the slower but highly potent and specific second line of defense, the adaptive immune system. The adaptive immune response calls on T lymphocytes as well as the B lymphocytes essential for the elimination of pathogens and the establishment of the immunological memory. Reactive oxygen species (ROS) have been implicated in many aspects of the immune responses to pathogens, mostly in innate immune functions, such as the respiratory burst and inflammasome activation. Here in this mini review, we focus on the role of ROS in adaptive immunity. We examine how ROS contribute to T-cell biology and discuss whether this activity can be extrapolated to B cells. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Bassoy, Walch and Martinvalet.) |
| Databáze: | MEDLINE |
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