Treating Metastatic Brain Cancers With Stem Cells.

Autor:	Sadanandan N; Georgetown University, Washington, DC, United States., Shear A; University of Florida, Gainesville, FL, United States., Brooks B; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States., Saft M; University of Michigan, Ann Arbor, MI, United States., Cabantan DAG; Michigan State University College of Osteopathic Medicine, East Lansing, MI, United States., Kingsbury C; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States., Zhang H; University of Florida, Gainesville, FL, United States., Anthony S; Lake Erie College of Osteopathic Medicine, Bradenton, FL, United States., Wang ZJ; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States., Salazar FE; Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud (FCS), Universidad Anáhuac México Campus Norte, Huixquilucan, Mexico., Lezama Toledo AR; Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud (FCS), Universidad Anáhuac México Campus Norte, Huixquilucan, Mexico., Rivera Monroy G; Centro de Investigación en Ciencias de la Salud (CICSA), Facultad de Ciencias de la Salud (FCS), Universidad Anáhuac México Campus Norte, Huixquilucan, Mexico., Vega Gonzales-Portillo J; Universidad Peruana de Ciencias Aplicadas, Lima, Peru., Moscatello A; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States., Lee JY; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States., Borlongan CV; Department of Neurosurgery and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.; Center of Excellence for Aging and Brain Repair, University of South Florida Morsani College of Medicine, Tampa, FL, United States.
Jazyk:	angličtina
Zdroj:	Frontiers in molecular neuroscience [Front Mol Neurosci] 2021 Nov 24; Vol. 14, pp. 749716. Date of Electronic Publication: 2021 Nov 24 (Print Publication: 2021).
DOI:	10.3389/fnmol.2021.749716
Abstrakt:	Stem cell therapy may present an effective treatment for metastatic brain cancer and glioblastoma. Here we posit the critical role of a leaky blood-brain barrier (BBB) as a key element for the development of brain metastases, specifically melanoma. By reviewing the immunological and inflammatory responses associated with BBB damage secondary to tumoral activity, we identify the involvement of this pathological process in the growth and formation of metastatic brain cancers. Likewise, we evaluate the hypothesis of regenerating impaired endothelial cells of the BBB and alleviating the damaged neurovascular unit to attenuate brain metastasis, using the endothelial progenitor cell (EPC) phenotype of bone marrow-derived mesenchymal stem cells. Specifically, there is a need to evaluate the efficacy for stem cell therapy to repair disruptions in the BBB and reduce inflammation in the brain, thereby causing attenuation of metastatic brain cancers. To establish the viability of stem cell therapy for the prevention and treatment of metastatic brain tumors, it is crucial to demonstrate BBB repair through augmentation of vasculogenesis and angiogenesis. BBB disruption is strongly linked to metastatic melanoma, worsens neuroinflammation during metastasis, and negatively influences the prognosis of metastatic brain cancer. Using stem cell therapy to interrupt inflammation secondary to this leaky BBB represents a paradigm-shifting approach for brain cancer treatment. In this review article, we critically assess the advantages and disadvantages of using stem cell therapy for brain metastases and glioblastoma. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Sadanandan, Shear, Brooks, Saft, Cabantan, Kingsbury, Zhang, Anthony, Wang, Salazar, Lezama Toledo, Rivera Monroy, Vega Gonzales-Portillo, Moscatello, Lee and Borlongan.)
Databáze:	MEDLINE
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