Risk of thyroid cancer in Ukrainian cleanup workers following the Chornobyl accident.

Autor: Gudzenko N; National Research Centre for Radiation Medicine, Kyiv, 04050, Ukraine., Mabuchi K; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA., Brenner AV; Radiation Research Effects Foundation, Hiroshima, Japan., Little MP; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA., Hatch M; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA., Drozdovitch V; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA., Vij V; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA., Chumak V; National Research Centre for Radiation Medicine, Kyiv, 04050, Ukraine., Bakhanova E; National Research Centre for Radiation Medicine, Kyiv, 04050, Ukraine., Trotsyuk N; National Research Centre for Radiation Medicine, Kyiv, 04050, Ukraine., Kryuchkov V; Burnasyan Federal Medical and Biophysical Centre, 46 Zhivopisnaya Street, Moscow, 123182, Russia., Golovanov I; Burnasyan Federal Medical and Biophysical Centre, 46 Zhivopisnaya Street, Moscow, 123182, Russia., Bazyka D; National Research Centre for Radiation Medicine, Kyiv, 04050, Ukraine., Cahoon EK; Radiation Epidemiology Branch, DCEG, Division of Cancer Epidemiology and Genetics, NIH, DHHS, National Cancer Institute, 9609 Medical Center Dr., Rm 7E542, Bethesda, MD, MS 9778, USA. cahoonek@mail.nih.gov.
Jazyk: angličtina
Zdroj: European journal of epidemiology [Eur J Epidemiol] 2022 Jan; Vol. 37 (1), pp. 67-77. Date of Electronic Publication: 2021 Dec 12.
DOI: 10.1007/s10654-021-00822-9
Abstrakt: Although much is known about the radiation-related risk of thyroid cancer in those exposed at young ages, less is known about the risk due to adult exposure, particularly in men. We aimed to examine the association between thyroid radiation dose received during adulthood and thyroid cancer risk in men. We conducted a nested case-control study (149 cases; 458 controls) of male, Ukrainian cleanup workers who first worked in the Chornobyl zone between ages 18 and 59 years, with cases identified through linkage with the National Cancer Registry of Ukraine from 1988 to 2012. Individual thyroid doses due to external and internal exposure during the cleanup mission and during residence in contaminated settlements were estimated (total dose mean 199 mGy; range 0.15 mGy to 9.0 Gy). The excess odds ratio per gray (EOR/Gy) for overall thyroid cancer was 0.40 (95% CI: - 0.05, 1.48; p-value = 0.118). Time since exposure was borderline significant (p-value = 0.061) in modifying this association so that less time since exposure was associated with a stronger EOR/Gy. An elevated, but nonsignificant association was observed for follicular thyroid cancer (EOR/Gy = 1.72; 95% CI: - 0.25, 13.69; p-value = 0.155) based on a small number of cases (n = 24). Our findings for radiation-related overall thyroid cancer risk are consistent with evidence of increased risks observed in most of the other studies of adult exposure, though the magnitude of the effect in this study is lower than in the previous case-control study of Chornobyl cleanup workers.
(© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.)
Databáze: MEDLINE
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