Electrochemical measuring of reactive oxygen species levels in the blood to detect ratio of high-density neutrophils, suitable to alarm presence of cancer in suspicious cases.

Autor: Miripour ZS; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran., Aminifar M; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran., Akbari ME; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Abbasvandi F; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P. O. Box 16 15179/64311, Tehran, Iran., Miraghaie SH; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran., Hoseinpour P; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; SEPAS Pathology Laboratory, P.O. Box: 1991945391, Tehran, Iran., Javadi MR; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Dabbagh N; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Mohajerzadeh L; Pathology Surgery Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Irang., Aghdam MK; Pediatric Pathology Research Center, Research Institute for Children Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran., Shamsian S; Pediatric Congenital Hematologic Disorders Research Center, Research Institute for Children's Health, Shahid Beheshti University of Medical Sciences, P.O. Box. 19395-4719, Tehran, Iran., Sanati H; ATMP Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, P. O. Box 16 15179/64311, Tehran, Iran., Abdolahad M; Nano Bio Electronic Devices Lab, Cancer Research Group, School of Electrical and Computer Engineering, College of Engineering, University of Tehran, P.O. Box 14395/515, Tehran, Iran; Institute of Cancer, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: m.abdolahad@ut.ac.ir.
Jazyk: angličtina
Zdroj: Journal of pharmaceutical and biomedical analysis [J Pharm Biomed Anal] 2022 Feb 05; Vol. 209, pp. 114488. Date of Electronic Publication: 2021 Nov 29.
DOI: 10.1016/j.jpba.2021.114488
Abstrakt: Here for the first time, a real-time electrochemical assay on unprocessed blood was designed to detect the presence of cancer in patients. The system has been based on the recently approved pathway, which indicates that the abundance of immature and mature low-density neutrophils (LDNs) with reduced ROS production in peripheral blood is increased with the presence of active cancer tumors. Reduced ROS/H 2 O 2 released from LDNs play the main role in determining the ROS/H 2 O 2 levels of peripheral blood. In contrast, HDNs with increased levels of released ROS/H 2 O 2 have higher concentrations than LDNs in normal cases. Hence, the reduced level of ROS species in peripheral blood recorded by our carbon nanostructure decorated sensor in less than 30 seconds showed a great pre-warning about the presence of non-treated cancer in patients with suspicious mass who have been sent for further evaluations.
Competing Interests: Declaration of Competing Interest The authors declare Iran Nano Fund is a financial interest that may be considered as a potential competing interest.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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