Antimicrobial-wound healing peptides: Dual-function molecules for the treatment of skin injuries.

Autor: de Souza GS; Unidade Acadêmica Ciências da Saúde, Universidade Federal de Jataí, Jataí, Goiás, Brazil., de Jesus Sonego L; Unidade Acadêmica Ciências da Saúde, Universidade Federal de Jataí, Jataí, Goiás, Brazil., Santos Mundim AC; Unidade Acadêmica Ciências da Saúde, Universidade Federal de Jataí, Jataí, Goiás, Brazil., de Miranda Moraes J; Unidade Acadêmica Ciências da Saúde, Universidade Federal de Jataí, Jataí, Goiás, Brazil., Sales-Campos H; Instituto de Patologia Tropical e Saúde Pública, Departamento de Biociências e Tecnologia, Universidade Federal de Goiás, Goiás, Brazil., Lorenzón EN; Unidade Acadêmica Ciências da Saúde, Universidade Federal de Jataí, Jataí, Goiás, Brazil. Electronic address: esteban@ufj.edu.br.
Jazyk: angličtina
Zdroj: Peptides [Peptides] 2022 Feb; Vol. 148, pp. 170707. Date of Electronic Publication: 2021 Dec 08.
DOI: 10.1016/j.peptides.2021.170707
Abstrakt: Chronic non-healing wounds caused by microbial infections extend the necessity for hospital care and constitute a public health problem and a great financial burden. Classic therapies include a wide range of approaches, from wound debridement to vascular surgery. Antimicrobial peptides (AMPs) are a preserved trait of the innate immune response among different animal species, with known effects on the immune system and microorganisms. Thus, AMPs may represent promising candidates for the treatment of chronic wounds with dual functionality in two of the main agents that lead to this condition, proliferation of microorganisms and uncontrolled inflammation. Here, our goal is to critically review AMPs with wound healing properties. We strongly believe that these dual-function peptides alone, or in combination with other wound healing strategies, constitute an underexplored field that researchers can take advantage of.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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