Deferral due to low hemoglobin and predictors of permanence in the blood donation system of repeat female blood donors.

Autor: Urbina A; Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud, Carrera 24 #63C-69, Quinta Mutis, Bogotá, D.C., Colombia. Electronic address: adriana.urbina@urosario.edu.co., García-Otálora MA; Universidad del Rosario, Escuela de Medicina y Ciencias de la Salud, Carrera 24 #63C-69, Quinta Mutis, Bogotá, D.C., Colombia., Mendoza-Romero D; Fundación Universitaria del Area Andina, Facultad de Ciencias de la Salud y el Deporte, Calle 69 #15-40, Bogotá, Colombia., Rocha F; Banco Nacional de Sangre, Cruz Roja Colombiana, Av Carrera 68 #68B-31, Bogotá, D.C., Colombia., Rodriguez A; Banco Nacional de Sangre, Cruz Roja Colombiana, Av Carrera 68 #68B-31, Bogotá, D.C., Colombia., Palomino F; FUATS, Carrera 70 #120-99, Bogotá, D.C., Colombia., Weinauer F; German RC Blood Services, Working Group of the GRC, Am Mühlberg 14 B Starnberg, D- 82319, Germany.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2022 Jun; Vol. 61 (3), pp. 103340. Date of Electronic Publication: 2021 Dec 09.
DOI: 10.1016/j.transci.2021.103340
Abstrakt: Objectives: To evaluate the deferral rate due to low hemoglobin (Hb) in repeat female blood donors and identify the factors affecting their permanence in the blood donation system.
Materials and Methods: 8,368 repeat female blood donors who donated from January 2012 to December 2018 were included. Bivariate analysis and Kaplan-Meier curves were used to identify the covariates possibly associated with developing low Hb, and Cox proportional hazards modeling was used to adjust for all confounders.
Results: The global deferral rate due to low Hb was 2.4 %. According to baseline Hb, the frequency of low Hb was 0.7-4.1 %, and it was higher in platelet donors (5.8-9.1 %) than in whole blood donors (1.9 %). The main predictors were baseline Hb (compared to the first quartile; hazard ratio [HR] = 0.487 for the second quartile; 0.234 for the third; and 0.095 for the fourth); change in Hb (HR = 2.689 for a >0.49 g/dL change, compared to smaller changes); the type of donation (compared to whole blood donors, HR = 2.317 for platelet donors); and donation interval (compared to >12.5 month intervals; HR = 2.220 for 8.0-12.5 months; HR = 5.658 for 5.4-8.0 months; and HR = 9.452 for <5.4 months).
Conclusions: In female blood donors at moderate altitude, the probability of developing low Hb increases with a baseline Hb of 13.5-14.0 g/dL, with a change in Hb >0.49 g/dL, in platelet donors, and with donation intervals <12.5 months. These four predictive factors can be used together for early identification of donors at risk of developing low Hb, to institute appropriate measures.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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