Motor training-related brain reorganization in patients with cerebellar degeneration.

Autor:	Draganova R; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Konietschke F; Institute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health (BIH), Berlin, Germany., Steiner KM; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Elangovan N; School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA., Gümüs M; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department of Neurosurgery, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Göricke SM; Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Ernst TM; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany., Deistung A; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.; Department for Radiation Medicine, University Clinic and Outpatient Clinic for Radiology, University Hospital Halle (Saale), Halle (Saale), Germany., van Eimeren T; Multimodal Neuroimaging Group, Department of Nuclear Medicine, University of Cologne, Cologne, Germany., Konczak J; School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA., Timmann D; Department of Neurology and Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2022 Apr 01; Vol. 43 (5), pp. 1611-1629. Date of Electronic Publication: 2021 Dec 11.
DOI:	10.1002/hbm.25746
Abstrakt:	Cerebellar degeneration progressively impairs motor function. Recent research showed that cerebellar patients can improve motor performance with practice, but the optimal feedback type (visual, proprioceptive, verbal) for such learning and the underlying neuroplastic changes are unknown. Here, patients with cerebellar degeneration (N = 40) and age- and sex-matched healthy controls (N = 40) practiced single-joint, goal-directed forearm movements for 5 days. Cerebellar patients improved performance during visuomotor practice, but a training focusing on either proprioceptive feedback, or explicit verbal feedback and instruction did not show additional benefits. Voxel-based morphometry revealed that after training gray matter volume (GMV) was increased prominently in the visual association cortices of controls, whereas cerebellar patients exhibited GMV increase predominantly in premotor cortex. The premotor cortex as a recipient of cerebellar efferents appears to be an important hub in compensatory remodeling following damage of the cerebro-cerebellar motor system. (© 2021 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.)
Databáze:	MEDLINE
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