Immunogenicity of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection and Ad26.CoV2.S Vaccination in People Living With Human Immunodeficiency Virus (HIV).

Autor:	Khan K; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Lustig G; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa., Bernstein M; Africa Health Research Institute, Durban, South Africa., Archary D; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Medical Microbiology, University of KwaZulu-Natal, Durban, South Africa., Cele S; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Karim F; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa., Smith M; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa., Ganga Y; Africa Health Research Institute, Durban, South Africa., Jule Z; Africa Health Research Institute, Durban, South Africa., Reedoy K; Africa Health Research Institute, Durban, South Africa., Miya Y; Africa Health Research Institute, Durban, South Africa., Mthabela N; Africa Health Research Institute, Durban, South Africa., Magula NP; Department of Medicine, King Edward VIII Hospital and University of KwaZulu Natal, Durban, South Africa., Lessells R; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa., de Oliveira T; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; KwaZulu-Natal Research Innovation and Sequencing Platform, Durban, South Africa.; Centre for Epidemic Response and Innovation, School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa.; Department of Global Health, University of Washington, Seattle, Washington, USA., Gosnell BI; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Abdool Karim S; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA., Garrett N; Centre for the AIDS Programme of Research in South Africa, Durban, South Africa.; Discipline of Public Health Medicine, School of Nursing and Public Health, University of KwaZulu-Natal, Durban, South Africa., Hanekom W; Africa Health Research Institute, Durban, South Africa.; Division of Infection and Immunity, University College London, London, United Kingdom., Bekker LG; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Desmond Tutu HIV Centre, Cape Town, South Africa., Gray G; South African Medical Research Council, Cape Town, South Africa., Blackburn JM; Department of Integrative Biomedical Sciences, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa.; Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, South Africa.; Sengenics Corporation, Kuala Lumpur, Malaysia., Moosa MS; Department of Infectious Diseases, Nelson R. Mandela School of Clinical Medicine, University of KwaZulu-Natal, Durban, South Africa., Sigal A; Africa Health Research Institute, Durban, South Africa.; School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.
Jazyk:	angličtina
Zdroj:	Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2022 Aug 24; Vol. 75 (1), pp. e857-e864.
DOI:	10.1093/cid/ciab1008
Abstrakt:	Background: People living with HIV (PLWH) have been reported to have a higher risk of more severe COVID-19 disease and death. We assessed the ability of the Ad26.CoV2.S vaccine to elicit neutralizing activity against the Delta variant in PLWH relative to HIV-negative individuals. We also examined effects of HIV status and suppression on Delta neutralization response in SARS-CoV-2-infected unvaccinated participants. Methods: We enrolled participants who were vaccinated through the SISONKE South African clinical trial of the Ad26.CoV2.S vaccine in healthcare workers (HCWs). PLWH in this group had well-controlled HIV infection. We also enrolled unvaccinated participants previously infected with SARS-CoV-2. Neutralization capacity was assessed by a live virus neutralization assay of the Delta variant. Results: Most Ad26.CoV2.S vaccinated HCWs were previously infected with SARS-CoV-2. In this group, Delta variant neutralization was 9-fold higher compared with the infected-only group and 26-fold higher relative to the vaccinated-only group. No decrease in Delta variant neutralization was observed in PLWH relative to HIV-negative participants. In contrast, SARS-CoV-2-infected, unvaccinated PLWH showed 7-fold lower neutralization and a higher frequency of nonresponders, with the highest frequency of nonresponders in people with HIV viremia. Vaccinated-only participants showed low neutralization capacity. Conclusions: The neutralization response of the Delta variant following Ad26.CoV2.S vaccination in PLWH with well-controlled HIV was not inferior to HIV-negative participants, irrespective of past SARS-CoV-2 infection. In SARS-CoV-2-infected and nonvaccinated participants, HIV infection reduced the neutralization response to SARS-CoV-2, with the strongest reduction in HIV viremic individuals. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu