Hunger Training as a Self-regulation Strategy in a Comprehensive Weight Loss Program for Breast Cancer Prevention: A Randomized Feasibility Study.

Autor:	Schembre SM; Department of Family and Community Medicine, The University of Arizona, College of Medicine-Tucson, Tucson, Arizona.; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Jospe MR; Department of Family and Community Medicine, The University of Arizona, College of Medicine-Tucson, Tucson, Arizona.; Department of Medicine, University of Otago, Dunedin, New Zealand., Bedrick EJ; Department of Epidemiology and Biostatistics, The University of Arizona, Mel and Enid Zuckerman College of Public Health, Tucson, Arizona., Li L; Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Brewster AM; Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, Texas., Levy E; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Dirba DD; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas., Campbell M; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas., Taylor RW; Department of Medicine, University of Otago, Dunedin, New Zealand., Basen-Engquist KM; Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Jazyk:	angličtina
Zdroj:	Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2022 Mar 01; Vol. 15 (3), pp. 193-201.
DOI:	10.1158/1940-6207.CAPR-21-0298
Abstrakt:	Weight losses >10% favorably modulate biomarkers of breast cancer risk but are not typically achieved by comprehensive weight loss programs, including the Diabetes Prevention Program (DPP). Combining the DPP with hunger training (HT), an evidence-based self-regulation strategy that uses self-monitored glucose levels to guide meal timing, has potential to enhance weight losses and cancer-related biomarkers, if proven feasible. This two-arm randomized controlled trial examined the feasibility of adding HT to the DPP and explored effects on weight and metabolic and breast cancer risk biomarkers. Fifty postmenopausal women [body mass index (BMI) >27 kg/m2)] at risk of breast cancer were randomized to the DPP+HT or DPP-only arm. Both arms followed a 16-week version of the DPP delivered weekly by a trained registered dietitian. Those in the DPP+HT also wore a continuous glucose monitor during weeks 4-6 of the program. Feasibility criteria were accrual rates >50%, retention rates >80%, and adherence to the HT protocol >75%. All a priori feasibility criteria were achieved. The accrual rate was 67%, retention rate was 81%, and adherence to HT was 90%. Weight losses and BMI reductions were significant over time as were changes in metabolic and breast cancer risk biomarkers but did not vary by group. This trial demonstrated that HT was feasible to add to comprehensive weight management program targeted toward postmenopausal women at high risk of breast cancer, though upon preliminary examination it does not appear to enhance weight loss or metabolic changes. Prevention Relevance: This study found that it was feasible to add a short glucose-guided eating intervention to a comprehensive weight management program targeting postmenopausal women at high risk of breast cancer. However, further development of this novel intervention as a cancer prevention strategy is needed. (©2021 American Association for Cancer Research.)
Databáze:	MEDLINE
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