100% Single Cell Encapsulation via Acoustofluidic Printing Based on a Gigahertz Acoustic Resonator.

Autor: Zhou Y, He M, Duan X
Jazyk: angličtina
Zdroj: Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2021 Nov; Vol. 2021, pp. 1172-1175.
DOI: 10.1109/EMBC46164.2021.9631051
Abstrakt: In this study, an acoustofluidic printing system for generation of single-cell droplets based on a gigahertz acoustic resonator was proposed and verified. The working area of the resonator has a typical dimension of 10×10 micrometer which is very suitable for single cell printing. Single cells were encapsulated in picoliter droplets and printed directly to a flat substrate without any significant influence on their viability. By combining an optic feed-back loop, a 100% single-cell encapsulation rate is achieved.Clinical Relevance- This acoustic-based system has good biocompatibility and high encapsulation rate, which expands the mechanism of medical and biology studies.
Databáze: MEDLINE