Alzheimer's disease and sleep disorders: Insights into the possible disease connections and the potential therapeutic targets.

Autor: Marde VS; National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India., Atkare UA; Institute of Pharmaceutical Education and Research, Borgaon (Meghe), Wardha, India., Gawali SV; University Department of Pharmaceutical Science, Nagpur, India., Tiwari PL; Springer Nature Technology and Publishing Solutions (SNTPS), India., Badole SP; IPDO, Dr. Reddy's Laboratory Ltd., Hyderabad 500090, India., Wankhede NL; Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, 441002 Nagpur, Maharashtra, India., Taksande BG; Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, 441002 Nagpur, Maharashtra, India., Upaganlawar AB; SNJB's Shriman Sureshdada Jain College of Pharmacy, Neminagar, Chandwad, Nashik 423101, India., Umekar MJ; Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, 441002 Nagpur, Maharashtra, India., Kale MB; Smt. Kishoritai Bhoyar College of Pharmacy, New Kamptee, 441002 Nagpur, Maharashtra, India. Electronic address: skbcopkmt@gmail.com.
Jazyk: angličtina
Zdroj: Asian journal of psychiatry [Asian J Psychiatr] 2022 Feb; Vol. 68, pp. 102961. Date of Electronic Publication: 2021 Dec 02.
DOI: 10.1016/j.ajp.2021.102961
Abstrakt: One of the comorbid conditions in an individual with Alzheimer's disease is a sleep disorder. Clinical features of sleep disorders involve various sleep disturbances such as Obstructive Sleep Apnea (OSAS), Excessive Daytime Sleepiness (EDS), Rapid Eye Movement (REM), Breathing Disorders, Periodic limb movements in sleep (PLMS), etc. The primary tools used for the identification of such disturbances are Polysomnography (PSG) and Wrist actigraphy. This review will highlight and explains the different approaches used in the treatment of sleep disorders. Non-pharmacological treatments include Peter Hauri rules, sleep education program, and light therapy which play a key role in the regulation of sleep-wake cycles. Pharmacological therapy described in this article may be useful in treating sleep destruction in patients with Alzheimer's disease. Along with the Non-pharmacological and pharmacological treatment, here we discuss five commonly recognized plant-based nutraceuticals with hypothesized impact on sleep disorders: caffeine, chamomile, cherries, L-tryptophan, and valerian by the proper emphasis on the known mechanism of their action.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: