Aging-Associated Changes in the Adult Human Skin Microbiome and the Host Factors that Affect Skin Microbiome Composition.

Autor:	Howard B; Procter & Gamble, Cincinnati, Ohio, USA., Bascom CC; Procter & Gamble, Cincinnati, Ohio, USA. Electronic address: bascom.cc@pg.com., Hu P; Procter & Gamble, Cincinnati, Ohio, USA., Binder RL; Procter & Gamble, Cincinnati, Ohio, USA., Fadayel G; Procter & Gamble, Cincinnati, Ohio, USA., Huggins TG; Procter & Gamble, Cincinnati, Ohio, USA., Jarrold BB; Procter & Gamble, Cincinnati, Ohio, USA., Osborne R; Procter & Gamble, Cincinnati, Ohio, USA., Rocchetta HL; Procter & Gamble, Cincinnati, Ohio, USA., Swift D; Procter & Gamble, Cincinnati, Ohio, USA., Tiesman JP; Procter & Gamble, Cincinnati, Ohio, USA., Song Y; Procter & Gamble, Cincinnati, Ohio, USA., Wang Y; Procter & Gamble, Cincinnati, Ohio, USA., Wehmeyer K; Procter & Gamble, Cincinnati, Ohio, USA., Kimball AB; Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA., Isfort RJ; Procter & Gamble, Cincinnati, Ohio, USA.
Jazyk:	angličtina
Zdroj:	The Journal of investigative dermatology [J Invest Dermatol] 2022 Jul; Vol. 142 (7), pp. 1934-1946.e21. Date of Electronic Publication: 2021 Dec 08.
DOI:	10.1016/j.jid.2021.11.029
Abstrakt:	Understanding the changes in the skin microbiome and their relationship to host skin factors during aging remains largely unknown. To better understand this phenomenon, we collected samples for metagenomic and host skin factor analyses from the forearm, buttock, and facial skin from 158 Caucasian females aged 20‒24, 30‒34, 40‒44, 50‒54, 60‒64, and 70‒74 years. Metagenomics analysis was performed using 16S ribosomal RNA gene sequencing, whereas host sebocyte gland area, skin lipids, natural moisturizing factors, and antimicrobial peptides measurements were also performed. These analyses showed that skin bacterial diversity increased at all the skin sites with increasing age. Of the bacterial genera with an average relative abundance >1%, only Lactobacillus and Cutibacterium demonstrated a significant change (decrease) in abundance at all sampled skin sites with increasing age. Additional bacterial genera demonstrated significant age- and site-specific changes in abundance. Analysis of sebocyte area, natural moisturizing factors, lipids, and antimicrobial peptides showed an age-related decrease in sebocyte area and increases in natural moisturizing factors/antimicrobial peptides/skin lipids, all of which correlated with changes in specific bacterial genera. In conclusion, the human skin microbiome undergoes age-associated alterations that may reflect underlying age-related changes in cutaneous biology. (Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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