Reproducing the effect of hippocampal network-targeted transcranial magnetic stimulation on episodic memory.

Autor: Freedberg MV; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA. Electronic address: michael.freedberg@austin.utexas.edu., Reeves JA; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA., Fioriti CM; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA., Murillo J; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA., Wassermann EM; National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Jazyk: angličtina
Zdroj: Behavioural brain research [Behav Brain Res] 2022 Feb 15; Vol. 419, pp. 113707. Date of Electronic Publication: 2021 Dec 07.
DOI: 10.1016/j.bbr.2021.113707
Abstrakt: Repetitive transcranial magnetic stimulation (rTMS) targeted to the hippocampal network via the inferior parietal cortex (HN-Stim) can strengthen hippocampal-cortical connectivity and improve episodic memory, offering a potential clinical intervention. However, acceptance of this technique has been tempered by the infrequent reproduction of findings in rTMS research on cognitive processes. We tested the reproducibility of the HN-Stim effect on episodic memory in our laboratory using different procedures from those previously published. We tested episodic memory in 29 participants before, one day, and one week after, three consecutive days of 20 Hz HN-Stim. Participants received stimulation targeted to either the area of inferior parietal cortex maximally connected to the left anterior hippocampus (HN-Stim; N = 14) or the vertex (control; N = 15), where we expected no effect. HN-Stim increased episodic memory performance one day, but not one week, after the last stimulation session. While failing to reproduce the lasting beneficial effect on memory found by others after five days of treatment, we found robust effects on behavior 24 h after treatment. HN-Stim is a safe and reliable means of enhancing episodic memory and may have potential for boosting learning and treating memory deficits.
(Copyright © 2021. Published by Elsevier B.V.)
Databáze: MEDLINE
Externí odkaz: