Preliminary comparative study of cortical thickness in HIV-infected patients with and without working memory deficit.

Autor: Cabral RF; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil., Corrêa DG; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Rio de Janeiro, Brazil., Zimmermann N; Department of Psychology, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Rio de Janeiro, Brazil., Tukamoto G; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil., Kubo TTA; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil., Fonseca RP; Department of Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Silva MM; Department of Neurology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Wilner NV; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Paulo Niemeyer State Brain Institute, Rio de Janeiro, Rio de Janeiro, Brazil., Bahia PRV; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil., Gasparetto EL; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.; Department of Radiology, Clínica de Diagnóstico por Imagem-Diagnósticos da America (CDPI-DASA), Rio de Janeiro, Rio de Janeiro, Brazil., Marchiori E; Department of Radiology, Hospital Universitário Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2021 Dec 10; Vol. 16 (12), pp. e0261208. Date of Electronic Publication: 2021 Dec 10 (Print Publication: 2021).
DOI: 10.1371/journal.pone.0261208
Abstrakt: Purpose: Changes in cerebral cortical regions occur in HIV-infected patients, even in those with mild neurocognitive disorders. Working memory / attention is one of the most affected cognitive domain in these patients, worsening their quality of life. Our objective was to assess whether cortical thickness differs between HIV-infected patients with and without working memory deficit.
Methods: Forty-one adult HIV-infected patients with and without working memory deficit were imaged on a 1.5 T scanner. Working memory deficit was classified by composite Z scores for performance on the Digits and Letter-Number Sequencing subtests of the Wechsler Adult Intelligence Scale (third edition; WAIS-III). Cortical thickness was determined using FreeSurfer software. Differences in mean cortical thickness between groups, corrected for multiple comparisons using Monte-Carlo simulation, were examined using the query design estimate contrast tool of the FreeSurfer software.
Results: Greater cortical thickness in left pars opercularis of the inferior frontal gyrus, and rostral and caudal portions of the left middle frontal gyrus (cluster 1; p = .004), and left superior frontal gyrus (cluster 2; p = .004) was observed in HIV-infected patients with working memory deficit compared with those without such deficit. Negative correlations were found between WAIS-III-based Z scores and cortical thickness in the two clusters (cluster 1: ρ = -0.59; cluster 2: ρ = -0.47).
Conclusion: HIV-infected patients with working memory deficit have regions of greater thickness in the left frontal cortices compared with those without such deficit, which may reflect increased synaptic contacts and/or an inflammatory response related to the damage caused by HIV infection.
Competing Interests: The authors have declared that no competing interests exist.
Databáze: MEDLINE
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