Young-onset diabetes patients in Thailand: Data from Thai Type 1 Diabetes and Diabetes diagnosed Age before 30 years Registry, Care and Network (T1DDAR CN).

Autor: Dejkhamron P; Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Northern Diabetes Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Santiprabhob J; Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Likitmaskul S; Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Deerochanawong C; Division of Endocrinology and Metabolism, Department of Medicine, College of Medicine, Rajavithi Hospital, Rangsit University, Bangkok, Thailand., Rawdaree P; Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Vajira Hospital, Navamindradhiraj University, Bangkok, Thailand., Tharavanij T; Endocrine and Metabolism Unit, Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.; Center of Excellence in Applied Epidemiology, Thammasat University, Bangkok, Thailand., Reutrakul S; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Kongkanka C; Endocrinology and Metabolism Unit, Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok, Thailand., Suprasongsin C; Research Center, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Numbenjapon N; Division of Endocrinology, Diabetes, and Metabolism, Department of Pediatrics, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand., Sahakitrungruang T; Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Lertwattanarak R; Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Engkakul P; Endocrinology and Metabolism Unit, Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand., Sriwijitkamol A; Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand., Korwutthikulrangsri M; Division of Endocrinology and Metabolism, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand., Leelawattana R; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkla, Thailand., Phimphilai M; Northern Diabetes Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand., Potisat S; Department of Medical Services, Ministry of Public Health, Nonthaburi, Thailand., Khananuraksa P; National Health Security Office (NHSO) of Thailand, Bangkok, Thailand., Kunsuikmengrai K; National Health Security Office (NHSO) of Thailand, Bangkok, Thailand., Nitiyanant W; Siriraj Diabetes Center, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Jazyk: angličtina
Zdroj: Journal of diabetes investigation [J Diabetes Investig] 2022 May; Vol. 13 (5), pp. 796-809. Date of Electronic Publication: 2022 Jan 06.
DOI: 10.1111/jdi.13732
Abstrakt: Aims/introduction: There is a lack of current information regarding young-onset diabetes in Thailand. Thus, the objectives of this study were to describe the types of diabetes, the clinical characteristics, the treatment regimens and achievement of glycemic control in Thai patients with young-onset diabetes.
Materials and Methods: Data of 2,844 patients with diabetes onset before 30 years-of-age were retrospectively reviewed from a diabetes registry comprising 31 hospitals in Thailand. Gestational diabetes was excluded.
Results: Based on clinical criteria, type 1 diabetes was identified in 62.6% of patients, type 2 diabetes in 30.7%, neonatal diabetes in 0.8%, other monogenic diabetes in 1.7%, secondary diabetes in 3.0%, genetic syndromes associated with diabetes in 0.9% and other types of diabetes in 0.4%. Type 1 diabetes accounted for 72.3% of patients with age of onset <20 years. The proportion of type 2 diabetes was 61.0% of patients with age of onset from 20 to <30 years. Intensive insulin treatment was prescribed to 55.2% of type 1 diabetes patients. Oral antidiabetic agent alone was used in 50.8% of type 2 diabetes patients, whereas 44.1% received insulin treatment. Most monogenic diabetes, secondary diabetes and genetic syndromes associated with diabetes required insulin treatment. Achievement of glycemic control was identified in 12.4% of type 1 diabetes patients, 30% of type 2 diabetes patients, 36.4% of neonatal diabetes patients, 28.3% of other monogenic diabetes patients, 45.6% of secondary diabetes patients and 28% of genetic syndromes associated with diabetes patients.
Conclusion: In this registry, type 1 diabetes remains the most common type and the prevalence of type 2 diabetes increases with age. The majority of patients did not achieve the glycemic target, especially type 1 diabetes patients.
(© 2021 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.)
Databáze: MEDLINE
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