| Autor: |
Armstrong T; School of Chemistry, Biodiscovery Institute, University Park, Nottingham University, Nottingham, NG7 2RD, UK., Fenn SJ; School of Life Sciences and National Biofilm Innovation Centre, Biodiscovery Institute, University Park, Nottingham University, Nottingham, NG7 2RD, UK., Hardie KR; School of Life Sciences and National Biofilm Innovation Centre, Biodiscovery Institute, University Park, Nottingham University, Nottingham, NG7 2RD, UK. |
| Abstrakt: |
Carbapenems are potent members of the β-lactam family that inhibit bacterial cell-wall biosynthesis inhibitors . They are highly effective against Gram-negative and Gram-positive drug-resistant infections . As such, carbapenems are typically reserved as an antibiotic of last resort. The WHO lists meropenem as an essential medicine. Nausea and vomiting are reported in ≤20% of carbapenem recipients, with 1.5% suffering seizures. Enzymatic hydrolysis of the β - lactam ring is the main driver of clinical resistance. These enzymes can be classified as Class A, B and D. Classes A and D are serine β - lactamases, whereas Class B rely on metal-mediated hydrolysis, typically through zinc. |
