Reduced Magnitude and Durability of Humoral Immune Responses to COVID-19 mRNA Vaccines Among Older Adults.

Autor:	Brockman MA; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Mwimanzi F; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Lapointe HR; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Sang Y; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Agafitei O; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Cheung PK; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Ennis S; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Ng K; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Basra S; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.; Department of Chemistry, Simon Fraser University, Burnaby, Canada., Lim LY; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada., Yaseen F; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada., Young L; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada., Umviligihozo G; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Omondi FH; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada., Kalikawe R; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Burns L; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada., Brumme CJ; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Leung V; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Montaner JSG; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.; Department of Medicine, University of British Columbia, Vancouver, Canada., Holmes D; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada., DeMarco ML; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada., Simons J; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, Providence Health Care, Vancouver, Canada., Pantophlet R; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada., Niikura M; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada., Romney MG; Division of Medical Microbiology and Virology, St Paul's Hospital, Vancouver, Canada.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada., Brumme ZL; Faculty of Health Sciences, Simon Fraser University, Burnaby, Canada.; British Columbia Centre for Excellence in HIV/AIDS, Vancouver, Canada.
Jazyk:	angličtina
Zdroj:	The Journal of infectious diseases [J Infect Dis] 2022 Apr 01; Vol. 225 (7), pp. 1129-1140.
DOI:	10.1093/infdis/jiab592
Abstrakt:	Background: The magnitude and durability of immune responses to coronavirus disease 2019 (COVID-19) mRNA vaccines remain incompletely characterized in the elderly. Methods: Anti-spike receptor-binding domain (RBD) antibodies, angiotensin-converting enzyme 2 (ACE2) competition, and virus neutralizing activities were assessed in plasma from 151 health care workers and older adults (range, 24-98 years of age) 1 month following the first vaccine dose, and 1 and 3 months following the second dose. Results: Older adults exhibited significantly weaker responses than younger health care workers for all humoral measures evaluated and at all time points tested, except for ACE2 competition activity after 1 vaccine dose. Moreover, older age remained independently associated with weaker responses even after correction for sociodemographic factors, chronic health condition burden, and vaccine-related variables. By 3 months after the second dose, all humoral responses had declined significantly in all participants, and remained significantly lower among older adults, who also displayed reduced binding antibodies and ACE2 competition activity towards the Delta variant. Conclusions: Humoral responses to COVID-19 mRNA vaccines are significantly weaker in older adults, and antibody-mediated activities in plasma decline universally over time. Older adults may thus remain at elevated risk of infection despite vaccination. (© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.)
Databáze:	MEDLINE
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