Depression among Tuberculosis patients and its association with treatment outcomes in district Srinagar.

Autor:	Rouf A; Department of Community Medicine, Government Medical College Anantnag., Masoodi MA; Department of Community Medicine, Government Medical College Anantnag., Dar MM; Department of Psychiatry, Government Medical College Srinagar., Khan SMS; Department of Community Medicine, Government Medical College Srinagar., Bilquise R; Department of Health services Kashmir.
Jazyk:	angličtina
Zdroj:	Journal of clinical tuberculosis and other mycobacterial diseases [J Clin Tuberc Other Mycobact Dis] 2021 Nov 15; Vol. 25, pp. 100281. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).
DOI:	10.1016/j.jctube.2021.100281
Abstrakt:	Background: Tuberculosis (TB) is among the top 10 causes of death worldwide and there are estimated 10.4 million new (incident) patients, of which about one fourth are in India. There has been calls for rigorous investigations and interventions that may address other factors known to have effect on adherence of treatment like Depression but the amount of research into comorbidity is surprisingly low. The aim of the study was to assess magnitude and impact of depression among TB patients and determine the treatment outcomes of TB in District Srinagar. Methods: In this prospective study the adults with newly diagnosed TB were recruited within one month of initiating treatment and were followed upto the end of treatment. Data collection was done at three time-points: baseline, after 2 months and after 6 months of treatment initiation. The sample size of 200 was calculated using OpenEpi, V3 and identified 202 TB patients were interviewed in their local language and PHQ-9 scale was used to measure Depression. Results: The prevalence of Depression at baseline was 50.5% with CI (43.7%-57.3%). After two months of treatment the prevalence reduced to 9.4% with CI (5.9%-14.0%) and at the end of treatment to 2.5% with CI (0.91%-5.4%). Association between Depression in TB patients and treatment failure was found to be small to medium as revealed by Cramer's V test (0.29-0.59). Binary logistic regression estimated that at baseline TB patients with Depression were at 4.46 times at more risk of treatment failure than patients without Depression and those patients who continued Depression even after intensive phase were 34.5 times at higher risk. Conclusion: Our findings indicate Depression is associated with poor treatment outcome in these patients, despite TB treatment. TB treatment strategies should consider screening and managing the psychologically distressed individuals among TB patients. Competing Interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (© 2021 The Author(s).)
Databáze:	MEDLINE
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