Transition kinetics of mixed lipid:photosurfactant assemblies studied by time-resolved small angle X-ray scattering.

Autor: Royes J; PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, Paris 75005, France., Bjørnestad VA; Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, Oslo N-0315, Norway., Brun G; PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, Paris 75005, France., Narayanan T; ESRF-The European Synchrotron, 71 Avenue des Martyrs, Grenoble F-38043, France., Lund R; Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, Oslo N-0315, Norway., Tribet C; PASTEUR, Département de chimie, École normale supérieure, PSL University, Sorbonne Université, CNRS, Paris 75005, France.
Jazyk: angličtina
Zdroj: Journal of colloid and interface science [J Colloid Interface Sci] 2022 Mar 15; Vol. 610, pp. 830-841. Date of Electronic Publication: 2021 Nov 24.
DOI: 10.1016/j.jcis.2021.11.133
Abstrakt: Hypothesis: Photoswitchable surfactants are used in the design of many light-responsive colloids and/or self-assemblies. Photo-isomerization enables to control molecular equilibrium, and triggers transient reorganizations with possibly out-of-equilibrium intermediate states that have been overlooked. Here, we address this question by an in depth structural investigation of intermediate lipid-surfactant assemblies that occur during fast isothermal photo-triggered transition in lipid:surfactant mixtures.
Experiments: The structural parameters of mixed assemblies of azobenzene-containing cationic surfactant (AzoTMA) and dioleoylphosphatidylcholine (DOPC) lipids were studied by light scattering and time-resolved small angle X-ray scattering. Structural and compositional information about the assemblies and unimers in bulk were determined at the photostationary states, as well as at intermediate kinetic states formed during UV or blue light illumination.
Findings: DOPC:AzoTMA systems form mixed assemblies representative of phospholipid:cationic surfactant mixtures, that evolve from spheroid, to rod-like micelles, and vesicles with increasing DOPC fraction. Transient assemblies detected during the photo-triggered kinetics are similar to the ones found in stationary states. But changes of AzoTMA unimers in bulk can be considerably faster than mass reorganizations of the mixed assemblies, suggesting that out-of-equilibrium conditions are transiently reached. Mass reorganization of the surfactant-enriched assemblies is much faster than in the lipid enriched ones, providing insight into the role of lipids in a slow reorganization of the assemblies.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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