Proliferation Activity in Canine Gastrointestinal Lymphoma.

Autor: Wolfesberger B; Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria. Electronic address: birgitt.wolfesberger@vetmeduni.ac.at., Burger S; VetCORE-Facility for Research, University of Veterinary Medicine, Vienna, Austria., Kummer S; VetCORE-Facility for Research, University of Veterinary Medicine, Vienna, Austria., Walter I; VetCORE-Facility for Research, University of Veterinary Medicine, Vienna, Austria., Tichy A; Department of Biomedical Sciences, University of Veterinary Medicine, Vienna, Austria., Klinger S; Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria., Alton K; Practice for Veterinary Pathology, Korneuburg, Austria., Burgener IA; Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria., Liehmann L; Department for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria., Hammer SE; Department of Pathobiology, University of Veterinary Medicine, Vienna., Rütgen BC; Department of Pathobiology, University of Veterinary Medicine, Vienna., Fuchs-Baumgartinger A; Department of Pathobiology, University of Veterinary Medicine, Vienna.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2021 Nov; Vol. 189, pp. 77-87. Date of Electronic Publication: 2021 Nov 13.
DOI: 10.1016/j.jcpa.2021.10.003
Abstrakt: Gastrointestinal lymphomas are uncommon in dogs and little is known about their distinct subtypes or proliferation rate. The aim of this study was to stratify 33 canine gastrointestinal lymphoma samples according to the latest World Health Organization classification and to determine the Ki67 proliferation index by manual counting, digital image analysis and visual estimation. The Ki67 index was then correlated with subtype, immunophenotype, mitotic index, grade and tumour location. The mitotic index correlated positively with the Ki67 index. A significantly higher number of Ki67-positive cells was found in enteropathy-associated T-cell lymphoma type I and in diffuse large B-cell lymphoma compared with enteropathy-associated T-cell lymphoma type II. There was also a significant difference in Ki67 immunolabelled cells between grade 1 and grade 2 lymphomas. Moderate agreement was found between the Ki67 index as obtained by manual counting and visual estimation, but there was strong agreement between manual counting and digital image analysis. The user-friendly digital imaging system used in this study could have potential for future determination of the Ki67 index in lymphoid neoplasms.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: