Histopathological Features of Spinal Cord Lesions in Dogs with Distemper-Associated Demyelinating Leucoencephalomyelitis.

Autor: Areco WVC; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Tondo LAS; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., de Avila NC; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Silva M; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., de Fighera RA; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., Kommers G; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil., de Flores MM; Department of Pathology, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil. Electronic address: marianamflores@yahoo.com.br., de Flores EF; Departament of Veterinary Preventive Medicine, Universidade Federal de Santa Maria, Santa Maria, Rio Grande do Sul, Brazil.
Jazyk: angličtina
Zdroj: Journal of comparative pathology [J Comp Pathol] 2021 Nov; Vol. 189, pp. 110-119. Date of Electronic Publication: 2021 Nov 17.
DOI: 10.1016/j.jcpa.2021.10.006
Abstrakt: Demyelinating leucoencephalomyelitis (DLEM) is one of the pathological presentations of canine distemper, but its histological characteristics and topographical distribution of spinal cord injuries have been poorly explored. Seventeen dogs submitted for necropsy to a veterinary pathology service (2006-2008) and diagnosed with distemper-associated DLEM were investigated. Seventy-two of 231 spinal cord sections from these animals had histological lesions, which consistently affected the white matter. The lumbosacral region was mostly affected (13/17), followed by the thoracolumbar (11/17), cervical (9/17) and cervicothoracic (9/17) regions. Among the 72 affected cord sections, lesions in the lateral (42/72) and dorsal funiculi (31/72) were the most common. Demyelination (17/17), astrocytosis (17/17), microgliosis (17/17), gemistocytes (11/17) and non-suppurative inflammation (10/17) were frequently seen in the white matter. Grey matter changes were less common, and included gliosis (8/17), non-suppurative inflammation (7/17) and malacia (5/17). Acute lesions were most prevalent (13/17) but it was common (10/17) for the same dog to have lesions at different stages of evolution in distinct spinal cord regions. Pathological changes in several spinal cords did not correlate with the reported clinical signs and some dogs did not present with spinal cord-related clinical signs. Our results highlight important aspects of the distribution and morphology of spinal cord lesions in dogs with distemper-associated DLEM, and may assist clinicians and pathologists in the diagnosis of spontaneous cases of this important infectious disease and contribute to further studies concerning distemper pathogenesis.
Competing Interests: Conflict of Interest Statement The authors declared no potential conflicts of interest with respect to the research, authorship or publication of this article.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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