| Autor: |
Graham CLB; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., Newman H; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., Gillett FN; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK.; School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Smart K; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., Briggs N; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK., Banzhaf M; School of Biosciences, University of Birmingham, Birmingham B15 2TT, UK., Roper DI; School of Life Sciences, University of Warwick, Coventry CV4 7AL, UK. |
| Abstrakt: |
Bacteria must maintain the ability to modify and repair the peptidoglycan layer without jeopardising its essential functions in cell shape, cellular integrity and intermolecular interactions. A range of new experimental techniques is bringing an advanced understanding of how bacteria regulate and achieve peptidoglycan synthesis, particularly in respect of the central role played by complexes of Sporulation, Elongation or Division (SEDs) and class B penicillin-binding proteins required for cell division, growth and shape. In this review we highlight relationships implicated by a bioinformatic approach between the outer membrane, cytoskeletal components, periplasmic control proteins, and cell elongation/division proteins to provide further perspective on the interactions of these cell division, growth and shape complexes. We detail the network of protein interactions that assist in the formation of peptidoglycan and highlight the increasingly dynamic and connected set of protein machinery and macrostructures that assist in creating the cell envelope layers in Gram-negative bacteria. |
