A 35-year follow-up study of patients admitted to methadone treatment between 1982-1984 in Asturias, Spain.

Autor: Jiménez-Treviño L; Universidad de Oviedo Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Instituto de Investigación Sanitaria del Principado de Asturias (ISPA) Servicio de Salud del Principado de Asturias (SESPA) Instituto de Neurociencias del Principado de Asturias (INEUROPA). luistrevino@eresmas.com., Martínez-Cao C, Sánchez-Lasheras F, Iglesias C, Antuña MJ, Riera L, Sáiz-Martínez PA, Bobes J
Jazyk: English; Spanish; Castilian
Zdroj: Adicciones [Adicciones] 2023 Sep 01; Vol. 35 (3), pp. 303-314. Date of Electronic Publication: 2023 Sep 01.
DOI: 10.20882/adicciones.1662
Abstrakt: The objective was to evaluate outcomes in a heroin-dependent population 35 years after first enrolment in methadone maintenance treatment (MMT).  An ad hoc protocol was used to assess drug misuse, treatment, and drug-related morbidity in the survivor sample. The standardized mortality ratio (SMR) and 95% confidence interval (CI) were calculated.  A total of 214 heroin-dependent patients entered MMT between 1982 and 1984 in the Asturias Public Health Service. Information was received on 195 subjects, of whom 146 were deceased.  Men accounted for 77.5% of the study cohort. Over the 35-year follow-up period, the SMR was 11.75 (95% CI = 9.95 - 13.77). In the survivor sample, 5.7% were still enrolled in MMT; human immunodeficiency virus (HIV) was diagnosed in 38.77% and hepatitis B/C in 73.46%. No differences were found between sexes in mortality or HIV and hepatitis B/C status. None of the female survivors were using heroin at the 35-year follow-up compared with 5.26% of males. In conclusion, our study confirms the high long-term mortality rate of heroin addicts, even after enrollment in MMT.
Databáze: MEDLINE